Rhubarb Multiple Organ Dysfunction Syndrome research and clinical application of the theory of.doc

 PAGE \* MERGEFORMAT 7 Rhubarb Multiple Organ Dysfunction Syndrome research and clinical application of the theory of Rhubarb for traditional Chinese medicine, with bowel catharsis, Xiehuo detoxification, blood circulation of the effect, in recent years, with the rhubarb in the treatment of critically ill patients the study continued to deepen, rhubarb in the treatment and prevention of multiple organ dysfunction syndrome (MODS ) theoretical research has matured and used in clinical treatment achieved significant results, try summarized below. A theoretical study Present rhubarb MODS research has focused on the protection of the gastrointestinal tract function, antagonize inflammatory mediators. While protecting important organs, removing oxygen free radicals, protecting the respiratory chain has also been reported. 1.1 Protection of gastrointestinal function Meakins et al (1985) proposed the pathogenesis of intestinal MODS yes “Start organ” of the well-known arguments. Clinical observation showed that more than 30% of patients died of sepsis and MODS associated with intestinal infection, but the lifetime inspection and autopsy after death can not find a clear Gan Ranzao. Animal studies have also shown: the gastrointestinal tract is the occurrence and development of MODS start moving organ. From the systemic inflammatory response is currently believed that the gastrointestinal tract in the pathogenesis of MODS has been damage not only the “target” organ, but also in the body under stress environmental stability and systemic inflammatory response key regulator. In recent years, prevention and treatment of MODS hot spots has been transferred to the digestive tract [1]. Prevention and treatment of gastrointestinal tract is considered the target organ MODS. Studies have shown that prolonged gastrointestinal mucosal injury, intestinal paralysis, increased pressure within the intestine caused by intestinal bacterial translocat