Rhodiola ultrafine powder in mice with acute liver injury in rats.doc

 PAGE \* MERGEFORMAT 9 Rhodiola ultrafine powder in mice with acute liver injury in rats [Abstract] of ultrafine powder and ethanol extract of Rhodiola rosea in mice with acute liver injury in rats, to compare the protective effect against liver damage difference. [Methods] D  galactosamine acute liver injury in mice produced animals models, respectively, to give different groups of mice were fed the appropriate dosage form and dose of ultrafine powder and ethanol extract of Rhodiola rosea, continuous 4d, the last administration in mice were measured after 1h of serum alanine transferase (ALT) and aspartate aminotransferase (AST) levels, liver homogenate malondialdehyde (MDA) content and superoxide dismutase (SOD) activity, while hepatic tissue biopsies, dyeing, the pathological changes observed. [Results] Rhodiola ultrafine powder and ethanol extract could significantly reduce the acute liver injury in mice serum ALT, AST and liver homogenate MDA, increased SOD activity. [Conclusion] Rhodiola ultrafine powder and ethanol extract of acute liver injury in mice has a protective effect were , while the role of superior superfine powder Rhodiola Rhodiola ethanol extract. [Keywords:] liver disease in mice Rhodiola ultrafine powder ABSTRACT: OBJECTIVETo study the protective effect of the ultra fine powder and the ethanol extracts of Rhodiola sachalimemsis A. Bor for acute liver injury in mice, and compare the protective effect to dose effect relationship between equal dose of them.METHODSThe mice performed by intragastric administration with the ultra fine powder and ethanol extract of Rhodiola sachalimemsis A. Bor, respectively. The mouse model of acute liver injury were induced by D  galactosamine, and the serum levels of ALT and AST and the contents of MDA, activity of SOD in livers of the mice were measured, and pathologic changes were observed.RESULTSThe groups of ultra fine powder and ethanol extract of the Rhodiola sachalimemsis A. Bor significantly red