Roxithromycin content of Charge Transfer Spectroscopy.docVIP

 PAGE \* MERGEFORMAT 19 Roxithromycin content of Charge Transfer Spectroscopy Keywords: roxithromycin 7 7 8 8  cyano-4-methyl-p-benzoquinone on the second charge transfer reaction spectrophotometry Spectrophotometric determination of roxithromycin ABSTRACT The charge transfer interactions between roxithromycin and 7,7,8,8  tetracyanoquinodimethane (TCNQ) were investigated by spectrophotometry. The apparent molar absorptivity of TCNQ complex is 1.57 × 104 L / (mol * cm) at 743nm, and 2.93 × 104 L / (mol * cm) at 844 nm; the result obeys Beers law in the concentration range of 0 ~ 55 mg / L. The relative standard deviation of the method is 1.0% (n = 6). The composition of complex of roxithromycin with 7,7,8,8  tetracyanoquinodimethane is 1:2. This proposed method has been applied to the determination of roxithromycin in tablets with satisfactory results. KEY WORDS Roxithromycin; 7,7,8,8  tetracyanoquinodimethane (TCNQ); Charge  transfer reaction; Spectrophotometry Charge transfer reaction, is defined as electron-rich and electron-deficient material and the formation of charge-transfer complex response, based on certain material generated by charge transfer complex with a specific color, such as the maximum absorption wavelength characteristics of the content of the material can be determined. The use of charge-transfer spectroscopy of drugs can be determined [1 ~ 9], nicotine [10], trace water in organic solvents [11,12] content, etc., because of this method is simple, rapid, reagent stability, good reproducibility, and therefore drug analysis has broad application prospects. Roxithromycin for the macrolide antibiotics, a major role in Gram-positive bacteria, anaerobes, chlamydia and so on. At present the method of determination of roxithromycin price method [13], voltammetry [14], SP method [15], HPLC method [16] and so on, but not been reported in the literature to 7,7,8,8  4 cyano-methyl-p-benzoquinone on the secondary