Salvia chronic obstructive pulmonary disease patients with MMP9 TIMP1 of.docVIP

 PAGE \* MERGEFORMAT 12 Salvia chronic obstructive pulmonary disease patients with MMP9 TIMP1 of Of: Wang Haixu Liu Bei Lin Qiman Coulee I keep Seoul Liping Liu Hui Zhao Jing LIU Hui-fang Xue Bing Zhang Xing [Abstract] Objective To investigate the SM with chronic obstructive pulmonary disease (COPD patients with acute exacerbation of MMP 9, TIMP 1. Methods choice in acute exacerbations of COPD and severe 60 patients were divided into A group (30 patients Salvia, B group (conventional group of 30 patients, a separate C group (30 cases of healthy control group. A group join on the basis of conventional therapy Danshen injection 800 mg, day 1 infusion, treatment 7 ~ 10 dA, B group patients in acute phase and after treatment were stable and the C group, respectively, by enzyme-linked immunosorbent assay of serum MMP 9, TIMP 1 levels, MMP 9/TIMP 1 ratio. The results A, B serum level of MMP 9, TIMP 1 levels, MMP 9/TIMP 1 ratio was significantly higher than the stability of the acute phase (P lt;0.05, stable group was higher than C (P lt;0.05, A group and B group, the acute phase serum levels of MMP 9 was no significant difference (Pgt; 0.05, in remission A MMP 9 levels were lower than B group (P lt;0.05, acute phase, remission phase serum levels of TIMP 1, MMP 9/TIMP 1 ratios were not statistically different (Pgt; 0.05. Conclusions MMP 9 in the airway inflammation in COPD process, TIMP 1 in the COPD airway repair process, in the pathogenesis of COPD, there is an imbalance MMP 9/TIMP 1, SM may inhibit matrix metalloproteinases, which have some protection for COPD patients and treatment. [Keywords:] Salvia, chronic obstructive pulmonary disease, MMP 9, TIMP 1, MMP 9/TIMP 1 Chronic obstructive pulmonary disease (COPD) in order to limit the gas is not fully reversible is characterized by airway inflammation, airway remodeling is the main pathological features. The collagen-based extracellular matrix in the airway wall is deposited over the wall caused by airw