Secure remote cutting edge of cancer research.docVIP

 PAGE \* MERGEFORMAT 15 Secure remote cutting edge of cancer research Keywords:: rectal cancer, adjacent transitional mucosa (TM) oncogene tumor suppressor gene safety margin So far, surgery is still the most effective means of treatment of rectal cancer. However, anastomotic recurrence is an important reason leading to surgical failure, anastomotic recurrence rate of about 5% to 15% [1]. Anastomotic recurrence due to various reasons, but not the length of distal bowel resection is a recognized fact. The distal bowel cancer resection length of the best scholars has been the focus of attention so far have been inconclusive. 1. The length of distal bowel resection is not enough lead to cause anastomotic recurrence The length of distal bowel resection led to anastomotic recurrence is not enough there are two main reasons: First, the proliferation of distal rectal cancer [2], including the cavity, cavity-proliferation [3], surgery has not been completely removed with cancer invasion distal intestines, caused by the proliferation of residual foci, anastomotic recurrence; second transitional mucosa in the distal bowel rectal histochemistry, cell proliferation kinetics, oncogenes and tumor suppressor genes at the molecular level there has been a significant change, with the normal colonic mucosa of different [4], has been considered in a state of precancerous lesions Moreover, patients with colon cancer tumor itself has a susceptibility, when these transitional mucosa affected by surgical stimulation and under the influence of factors in the carcinogenic Yi evil into a new cancer [ 2]. 2. Rectal cancer proliferation issues related to the remote (A) factors, the proliferation of methods and their captive distal rectal cancer or cancer cell proliferation through direct spread along the lymphatic, blood vessels and nerves to the distal bowel infiltration, its intramural spread occurrence rate of about 6.5% ~ 26% [3], Among them, the direct spread of the spread is a