The molecular basis of cancer targeted therapy.docVIP

 PAGE \* MERGEFORMAT 27 The molecular basis of cancer targeted therapy [Abstract] gastric cancer mortality in the global mortality rate ranked second, while in China, Japan, Korea and other Asian countries, the mortality rate is topping the list. Unfortunately, most cancer patients are diagnosed at advanced stage disease has, At this point the traditional surgery, chemotherapy and radiation therapy can effectively reduce the mortality rate of patients. In recent decades a new mode of treatment - cancer molecular target therapy anti-cancer therapy is gradually occupy their own arena, and shows a good prospect. This paper will present the research focus, research in our laboratory, from the targeted molecular screening of gastric cancer and application of adjustment of the tumor micro-environment and anti-tumor immune therapy three aspects of gastric cancer targeted therapy to be an overview of the molecular basis. [Keywords:] cancer, targeted therapy, immunotherapy ABSTRACT: Gastric cancer is the second leading cause of cancer mortality worldwide, and in Asian countries like Japan, Korea and China, it remains the top killing cancer. As most cases of gastric cancer are in the advanced stage of the disease when they are first diagnosed, patients receiving conventional therapies including surgery, chemotherapy and radiotherapy have poor prognosis. An emerging modality called tumor molecular targeted therapy provides promise and insight to combat this malignancy. This article discusses the molecular basis of gastric cancer targeted therapy from the perspectives of screening and application of target molecules, modulation of tumor microenvironment and antitumor immunotherapy. KEY WORDS: gastric cancer; targeted therapy; immunotherapy Is the world’s highest incidence of gastric cancer, one of nearly a million new cases each year, of which about 2 / 3 of the patients from developing countries, China alone accounted for 42% [1], while gastric cancer is th