The problem of protein folding.docVIP

 PAGE \* MERGEFORMAT 19 The problem of protein folding Abstract: The structure and function of biological macromolecules of the study is to understand the molecular level the basis of the first elephant. Not the structure and function of biological macromolecules knowledge, there is no molecular biology. Just as no discovery of double helix structure of DNA, there is no central dogma of genetic message delivered, there is not today’s molecular biology. Structure of molecules from the first elements entered the right and objects as well as multi-subunit complex, multi-molecular complex and body structure. At the same time, in the past difficult to study life on the molecular level of the movement of the study in-depth and in tandem with the development of technical means to gradually become a hot spot by the difficulty. Protein crystallography studies of biological macromolecules from static (time statistics) structural analysis begun to enter the dynamic (time-resolved) structure analysis and dynamic analysis. 13th session of the International Biophysics Congress of the 25 symposia, more than half related to protein structure and function, while the ‘structure and function’ also stressed that ‘Dynamics (Dynamics)’, that is, the structure or the structure of dynamic movement and function relationships of protein molecules, as well as the contribution of macromolecular interactions. Keywords: protein; biological macromolecules; molecular chaperone; Folding Problem Abstract: Biological macromolecule’s structure and the function research is understands the molecular level the first alike foundation. Not to biological macromolecule’s structure and the function understanding, does not have the molecular biology. Just like does not have the DNA double helix structure discovery, has not inherited the transmission transmission the central dogma, also does not have today’s molecular biology. The structure member by enters by the first member to restores peace the thin