Transfusion of platelets in vivo clearance mechanism of Progress.docVIP

 PAGE \* MERGEFORMAT 23 Transfusion of platelets in vivo clearance mechanism of Progress 【Abstract】 physiology, pathology studies have found platelet clearance in the body mainly in the liver and spleen, but the aging and injury in vivo platelet clearance system has been the identification and clearance mechanisms is not clear. In-depth study of this mechanism will help to solve the platelet in vivo survival after cryopreservation and short and can not play a role in longer-term problem, in order to propose a new strategy for platelet preservation. In this paper, platelet transfusion in vivo clearance mechanisms, including P-selectin, GP Ⅰ bα and its receptor Mac-1 and endogenous metalloproteinases in platelet clearance process, the role of the research are reviewed. 【Key Words】 Platelet; platelet preservation; removal mechanisms; P-selectin; GP Ⅰ bα; endogenous metalloproteinase Advances in the Studies of the Clearance Mechanism of Transfused Platelet Concentrates - Review AbstractPlatelet clearance has already been studied in physiological and pathological conditions and shown its occurrence mainly in the liver and the spleen. It is still not clear what mechanisms are responsible for recognition and removal of either aged or damaged platelets by the scavenging system. So study of the clearance mechanism will be useful to prolong the survival time of plateletes in vivo. And it may be related to a new strategy to store platelets. This article focuses on the advances in studies of the clearance mechanism of transfused platelet concentrates, including roles of P -selectin, GP Ⅰ bα and its rectptor Mac-1 in platelet clearance, and effect of endogenous metalloproteinase in platelet clea-rance. Keywords:platelet; platelet preservation; clearance mechanism; P-selectin; GP Ⅰ bα; endogenous metalloproteinase Platelet products in clinical transfusion therapy has an important role in the massive loss of blood and chemotherapy, r