Tumor angiogenesis inhibitor - endostatin in cancer research_0.docVIP

 PAGE \* MERGEFORMAT 22 Tumor angiogenesis inhibitor - endostatin in cancer research [Abstract] tumor growth and metastasis are inseparable from the generation of new blood vessels, tumor endostatin is derived from the basement membrane collagen IV (Col IV) protein fragments with anti-tumor angiogenesis and inhibit tumor cell proliferation in a double activity, can specifically inhibit vascular endothelial cell protein synthesis. Their further studies confirmed Tumstatin is an endogenous inhibitor of pathological angiogenesis, with potential medicinal value. This paper mainly outlines the source of tumstatin, structure and distribution, activity, mechanism and its relationship with matrix metalloproteinase (MMP) the relationship between the latest research advances and application prospects. [Keywords:] Tumstatin; tumor angiogenesis inhibitor; endothelial cell; α vβ 3 integrin - Advances of an inhibitor of tumor angiogenesis-Tumstatin [Abstract] Tumors cannot grow or metastasize without the recruitment of new blood vessels. Tumstatin is a C-terminal NC1 fragment of type IV collagen α 3 chain that inhibits pathological angiogenesis and suppresses proliferation of endothelial cells and growth of tumors. Further studies suggest that tumstatin is an endogenous inhibitor of pathological angiogenesis. This review introduced the origin, structure and distribution of tumstatin; the biological activity of tumstatin; the mechanism of tumstatin and the relationship between tumstatin and matrix metalloproteinases; the futures of tumstatin. [Keywords:] tumstatin; inhibitor of tumor angiogensis; endothelial cell; α vβ 3 integrin Angiogenesis refers to mature blood vessels from pre-existing capillary network to form a new process, the process for vertebrate development and physiology repair of damaged tissue is necessary, while the pathogenesis of many diseases are related to angiogenesis , including tumor growth, cardiovascular disease, diabetic retinopathy,