Yuhong Ointment on the process of wound healing epidermal proliferation and differentiation of stem cells.docVIP

 PAGE \* MERGEFORMAT 28 Yuhong Ointment on the process of wound healing epidermal proliferation and differentiation of stem cells Study: Fan-Fei, Huang Qingyi, Konghuan Yu, Li Li, Yang Liping, Zhu Xi [Abstract] Objective To observe Yuhong ointment on epidermal stem cell proliferation, differentiation, Yuhong Ointment promote wound healing of the mechanism. Methods The rat full-thickness skin defect model, Yuhong Ointment completely randomly divided into groups, Jing Wan Hong group, model group, normal control group. In the days after modeling, 1,3,5,7,14,21 6 time observation wound healing, complete healing time and drawn. OK epidermal stem cell marker integrin β1, transcription factor p63 immunohistochemical staining were compared among groups of observation points OD value and positive cell number. The results of Yu The mean healing time of red paste [(13.5 + -0.9) d] and Jing Wan Hong group [(12.6 + -0.9) d] no significant differences were better than the model group [(19.1 ± 2.6) d], P lt; 0.05, see Yuhong Ointment general observation group and the early wound exudate more thick; integrin β1, transcription factor p63 immunohistochemical staining showed that Yuhong cream group, Jing Wan Hong group, model group modeling integrin β1 OD value after the transcription factor p63 positive cells in the epidermis were higher than the normal group, and the difference significant (P lt;0.05), Yuhong cream group, Jing Wan Hong group peaked at 7 days , the peak occurred earlier in the model group, the peak intensity than the model group, the difference significant (P lt;0.05), Yuhong Ointment target group before the 2 14 d were higher than model group (P lt;0.05), Beijing million in the red group before 7 d higher than model group (P lt;0.05), the first 14 days no difference with model group, until the wounds healed completely in 21 days no difference in Group 3. Conclusion Yuhong Ointment can promote wound healing, the mechanism the wound edge may be related to