Yunnanbaiyao on inflammatory status in spontaneously hypertensive rats improved renal function.docVIP

 PAGE \* MERGEFORMAT 21 Yunnanbaiyao on inflammatory status in spontaneously hypertensive rats improved renal function Of: Tiandeng Ke, Gang collar, CIVIL, Hu sent to friends, Liu, Bian card [Abstract] Objective To observe Yunnanbaiyao (YNBY) in spontaneously hypertensive rats (SHR) kidney inflammation, and to explore its role in the prevention and treatment of hypertension and renal disease. METHODS YNBY to 6 weeks old SHR were divided into treatment group and hypertension model control group, the three time points (6 weeks delivery, delivery 14 weeks, 9 weeks after treatment) study YNBY blood pressure of SHR, renal expression of inflammatory cytokines and oxidative stress. The results YNBY no significant antihypertensive effect on SHR (Pgt; 0.05). YNBY mRNA and protein levels in the inhibition of the expression of intercellular adhesion molecule -1 (ICAM-1) and endothelial nitric oxide synthase (eNOS) in the SHR kidney high expression (P lt;0.05). YNBY withdrawal in the administration of 14 weeks and 9 weeks reduced the peroxisome proliferator-activated receptor (PPAR) in mRNA expression (P lt;0.05), 14 weeks in the administration significantly reduced the PPAR protein expression (P lt;0.05). YNBY after administration significantly reduced the SHR kidney tissue protein carbonyl level (P lt;0.05), in the administration of 14 weeks and withdrawal after 9 weeks could significantly increase the SHR kidney total anti- oxidative capacity (P lt;0.05). Conclusion YNBY after administration to SHR significantly reduced renal inflammation and oxidative stress, YNBY may nephropathy in the control of hypertension has a certain effect. [Keywords:] Yunnanbaiyao; spontaneously hypertensive rats; hypertensive renal disease; inflammatory response Abstract: ObjectiveTo investigate the effects of YunNanBaiYao (YNBY) on inflammatory status of the kidney from spontaneously hypertensive rats (SHR), and to explore preventive and therapeutic usage of YNBY on hypertensive