Comparison of Glycated Albumin (GA) and Glycosylated Hemoglobin (A1C) in monitoring glycemic excursions during pregnancy.docVIP

Open Journal of Obstetrics and Gynecology, 2013, 3, 47-50 OJOG /10.4236/ojog.2013.31011 Published Online January 2013 (/journal/ojog/) Comparison of Glycated Albumin (GA) and Glycosylated Hemoglobin (A1C) in monitoring glycemic excursions during pregnancy Veeraswamy Seshiah , Vijayam Balaji , Ashalatha Srinivasan , Madhuri S. Balaji , Arthi Thiyagarajah 1 1 1 1 2 1 2 Dr. V. Seshiah Diabetes Research Institute, Dr. Balaji Diabetes Care Centre, Chennai, India Nutrition and Clinical Research Department, Dr. V. Seshiah Diabetes Research Institute, Dr. Balaji Diabetes Care Centre, Chennai, India Email: vseshiah@ Received 3 October 2012; revised 6 November 2012; accepted 15 November 2012 ABSTRACT are at increased risk of developing serious complications compared with the non-diabetic pregnant women, include- ing spontaneous abortion, preterm labor, hypertensive disorders, and delivery by cesarean section despite im- proved access and quality of antenatal care [1]. Women diagnosed to have gestational diabetes mellitus (GDM) during pregnancy also do develop similar complications, though not of same magnitude. Gestational diabetes mel- litus accounts for ~90% of cases where pregnancy is complicated by diabetes [2], with potentially long-reach- ing consequences, including increasing the risk of sub- sequently developing type 2 diabetes for both mother and child [3]. Disrupted metabolic homeostasis has been im- plicated as a possible cause [4]; indeed, fetal macrosomia may result from minor disturbances in glucose metabo- lism [5]. These observations indicate an optimum glyce- mic control is essential to minimize the maternal and fetal morbidity and mortality of pregnancies complicated by glucose intolerance [6]. This i