Aquaporin 1-expressing MCF-7 mammary carcinoma cells show enhanced migration in vitro英文文献资料.docVIP

J. Biomedical Science and Engineering, 2010, 3, 95-100 JBiSE doi:10.4236/jbise.2010.31014 Published Online January 2010 (http://www.SciRP.org/journal/jbise/). Aquaporin 1-expressing MCF-7 mammary carcinoma cells show enhanced migration in vitro Yong Jiang , Zhi-Bin Jiang 1,2 3 1 2 3 Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, China; College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China; Jilin Combined Traditional Chinese and Western Medicine Hospital in Jilin Province, Jilin, China. Email: jiangyong@ Received 6 September 2009; revised 19 October 2009; accepted 20 October 2009. ABSTRACT other species have been identified molecularly [2,3]. Aquaporins (AQPs) are membrane water channels that play pivotal roles in physiological and pathophysiologi- cal processes of diverse mammalian organs [4,5,6]. Re- cent studies indicated a novel role of AQPs in cell mi- gration. Mice lacking AQP1, the endothelial water channel, were found to have impaired endothelial cell migration and tumor angiogenesis [7]. In the same study, over-expression of AQP1 or AQP4 (a structurally related water channel) was also found to promote migration of non-endothelial cells. Subsequent studies demonstrated that AQP1 expression promoted the migration of epithe- lial cells of kidney proximal tubules and facilitated wound healing of injured proximal tubules [8]. In the brain, AQP4 deletion in astroglial cells was also found to result in impaired migration and remarkably reduced glial scar formation after stab injury [9]. In addition, some other studies provided evidence that aquaglycero- porin AQP9 may be involved in neutrophil cell motility [10,11]. These studies suggested that aquaporin-Mediat- ed plasma membrane water permeability may be a fun- damental determin