Association of the CLC-Kb T481S polymorphism with childhood hypertension英文文献资料.docVIP

Vol.2, No.7, 682-684 (2010) Health doi:10.4236/health.2010.27103 Association of the CLC-Kb T481S polymorphism with childhood hypertension Rainer Büscher University of Duisburg-Essen, Children’s Hospital, Pediatrics II, Essen, Germany; rainer.buescher@uk-essen.de Received 17 March 2010; revised 29 March 2010; accepted 31 March 2010. ABSTRACT 1. INTRODUCTION Essential hypertension is a difficult diagnosis in children and the gene of the renal-epithelial chloride channel ClC-Kb is potentially predis- posing. In vitro studies have shown that a co- mmon ClC-Kb threonine481serine (T481S) poly- morphism leads to enhanced chloride channel activity and may predispose for hypertension (HT). We therefore analysed children at risk for HT for the T481S polymorphism and associ- ated genotype with blood pressure (BP) status. A total of 48 children with essential hyperten- sion (mean age 14.4 ± 2.7 years, 26 male; 22 female; mean BP 143.4 ± 7.5/88 ± 5.8 mmHg) were compared with 78 children with white-coat HT (WCHT), who showed occasionally hyper- tensive BP values, which were not confirmed by ambulatory blood pressure monitoring (mean age 13.7 ± 2.5 years, 49 male, 29 female; mean BP 122.4 ± 4.3/68.2 ± 3.5 mmHg). Other causes of HT were excluded. Allelic frequencies of hy- pertensive patients were not significantly dif- ferent from those with WCHT (HT: A 0.84; T 0.16 vs. WCHT: A 0.85; T 0.15). However, the T-allele was observed more frequently in WCHT sub- jects with systolic and diastolic BP exceeding the 90th percentile (A 0.71; T 0.29, n = 34, p 0.05, considered as borderline hypertensive). The preliminary data suggest that children with WCHT carry the ClC-Kb T481S polymorphism more often and that this variant may predispose for development of arterial HT. Essential hypertension in childhood is rare and in most cases, diagnosis can only be confirmed by ex