Association of Polymorphisms in the Human IL4 and IL5 Genes with Atopic Bronchial Asthma and Severity of the Disease英文文献资料.docVIP

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Association of Polymorphisms in the Human IL4 and IL5 Genes with Atopic Bronchial Asthma and Severity of the Disease英文文献资料.doc

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Association of Polymorphisms in the Human IL4 and IL5 Genes with Atopic Bronchial Asthma and Severity of the Disease英文文献资料

ComparativeandFunctionalGenomics CompFunctGenom2003;4 :346–350. PublishedonlineinWileyInterScience().DOI:10.1002/cfg.293 ShortCommunication Associationofpolymorphismsinthehuman IL4andIL5geneswithatopicbronchial asthmaandseverityofthedisease MaximB.Freidin1,OlgaS.Kobyakova2,LudmilaM.Ogorodova2andValeryP.Puzyrev1,3* 1Population Genetics Laboratory, Research InstituteforMedicalGenetics, Tomsk,Russia 2Department ofPediatrics, SiberianStateMedicalUniversity, Tomsk,Russia 3Department ofMedicalGenetics, Siberian StateMedicalUniversity, Tomsk,Russia *Correspondence to: Abstract ValeryP.Puzyrev, Research InstituteforMedicalGenetics, 10 Nab.r.UshaikyAve.,634050 Tomsk,Russia. Twopolymorphisms intheIL4(G/C3-UTR)andIL5(C-703T) geneswerestudiedin asample offamilies whose probands had atopic bronchial asthma (BA) (66families, n =183)andinagroupofnon-cognate individuals withthesevereformofthedisease (n =34).ThesampleswerecollectedfromtheRussianpopulationinthecityofTomsk (Russia). Using the transmission/disequilibrium test (TDT), a signi?cant association ofallele C-703 IL5 with BA wasestablished (TDT=4.923, p =0.007± 0.0007). The analysis of 40 individuals with mild asthma and 49 patients with the severe form of the disease revealed a negative association of genotype GG IL4 (OR=0.39, 95% CI=0.15–0.99, p =0.035), and also a trend towards a positive association of the GC IL4genotype (OR=2.52,95% CI=0.98–6.57,p =0.052) with mild BA. There was a concordance of the clinical classi?cation of BA severity with the ‘genotype’ E-mail:valery@img.tsu.ru. (McNemar’s X test with continuity correction constituted 0.03, d.f.=1,p =0.859). 2 These results suggest that polymorphisms intheIL4 and IL5 genes contribute tothe susceptibility to atopic BA and could determine the clinical course of the disease. Copyright ?2003 John Wiley Sons, Ltd. Keywords: association atopic bronchial asthma; candidate genes; IL4; IL5 ; polymorphism; Accepted:31March2003 Introduction been investigated. Ex