Associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men An electron spin resonance investigation英文文献资料.docVIP

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Associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men An electron spin resonance investigation英文文献资料.doc

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Associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men An electron spin resonance investigation英文文献资料

Advances in Bioscience and Biotechnology, 2012, 3, 1020-1027 ABB /10.4236/abb.2012.327124 Published Online November 2012 (http://www.SciRP.org/journal/abb/) Associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men: An electron spin resonance investigation Kazushi Tsuda 1,2 1 2 Cardiovascular and Metabolic Research Center, Kansai University of Health Sciences, Osaka, Japan Division of Cardiology, Department of Medicine, Wakayama Medical University, Wakayama, Japan Email: tsudak@mail.wakayama-med.ac.jp Received 19 August 2012; revised 27 September 2012; accepted 13 October 2012 ABSTRACT rheologic behavior of RBCs and microcirculatory dysfunction in hypertensive men. There is evidence showing that increased levels of oxidative stress and C-reactive protein (CRP) might be associated with obesity, hypertension, atheroscle- rosis and other cardiovascular diseases. This study was undertaken to investigate possible relationships among plasma 8-iso-prostaglandin F2α (8-iso-PG F2α: an index of oxidative stress), high-sensitivity (hs)- CRP and membrane fluidity (a reciprocal value of microviscosity) in hypertensive and normotensive men using an electron spin resonance (ESR)-method. The order parameter (S) for the spin-label agents (5- nitroxide stearate) of red blood cell (RBC) mem- branes in the ESR spectra was significantly higher in hypertensive men than in normotensive men, indi- cating that membrane fluidity was decreased in hy- pertensive men. Both plasma 8-iso-PG F2α and hs- CRP levels were significantly increased in hyperten- sive men compared with normotensive men. In addi- tion, plasma plasma 8-iso-PG F2α levels were corre- lated with plasma hs-CRP levels. In contrast, plasma nitric oxide (NO)-metabolites were lower in hyper- tensive men than in normotensive me