Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia英文文献资料.docVIP

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Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia英文文献资料.doc

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Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia英文文献资料

HindawiPublishingCorporation JournalofToxicology Volume2012,ArticleID648384,8pages doi:10.1155/2012/648384 ClinicalStudy ApplicationofPuri?edBotulinumTypeANeurotoxinto TreatExperimentalTrigeminalNeuropathyinRatsandPatients withUrinaryIncontinenceandProstaticHyperplasia YoshizoMatsuka, Ni Nengah Dwi Fatmawati, TakuoKuboki, AtsushiNagai, 1 TeruhikoYokoyama, Atsushi Nishikawa, andKeijiOguma 2 YumikoYamamoto, 4 3 TomonoriSuzuki, 3 3 Tohru Ohyama, Toshihiro Watanabe, 5 5 1 2 3 1 DepartmentofOralRehabilitationandRegenerativeMedicine,OkayamaUniversityGraduateSchoolofMedicine, DentistryandPharmaceuticalSciences,Okayama700-8558,Japan 2 3 DepartmentofUrology,KawasakiMedicalSchool,Kurashiki701-0192,Japan Department ofMedicalBacteriology,Okayama UniversityGraduateSchoolofMedicine,Dentistry andPharmaceutical Sciences, 2-5-1Shikata-cho,Okayama700-8558,Japan 4 5 DepartmentofAppliedBiologicalScience,TokyoUniversityofAgricultureandTechnology,Tokyo183-8509,Japan DepartmentofFoodandCosmeticScience,FacultyofBioindustry,TokyoUniversityofAgriculture,Abashiri099-2493,Japan CorrespondenceshouldbeaddressedtoKeijiOguma,kuma@md.okayama-u.ac.jp Received25July2011;Revised15February2012;Accepted10April2012 AcademicEditor:S.AshrafAhmed Copyright?2012YoshizoMatsukaetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. TypeAneurotoxin(NTX)ofClostridiumbotulinumwaspuri?edbyasimpleprocedureusingalactosegelcolumn.Thetoxicityof thispuri?edtoxinpreparationwasretainedforatleast1yearat?30 Cbysupplementationwitheither0.1%albuminor0.05% ? albuminplus1%trehalose.Whenpuri?edNTXwasusedtotreat49patientswithurinaryincontinencecausedbyeitherrefractory idiopathicorneurogenicdetrusoroveractivity,36patientsshowedsigni?cantimprovementinsymptoms.Thesebene?ciale?ects werealsoobservedincasesofprostatichyperplasia.TheresultsobtainedwithNTX