Behavior of CD44 Receptors in Mammary Tumors of Dogs英文文献资料.docVIP

Open Journal of Veterinary Medicine, 2012, 2, 48-51 /10.4236/ojvm.2012.22008 Published Online June 2012 (http://www.SciRP.org/journal/ojvm) Behavior of CD44 Receptors in Mammary Tumors of Dogs Geórgia M. Magalh?es , Ana Carolina T. Silveira , Danísio P. Munari , Antonio C. Alessi 1 2 1 1 1 Department of Veterinary Pathology, Sao Paulo State University, Sao Paulo, Brazil Department of Animal Science, Sergipe Federal University, Sergipe, Brazil Email: georgiamode@ 2 Received January 5, 2012; revised February 20, 2012; accepted April 5, 2012 ABSTRACT CD44 is a cell adhesion molecule closely related to tumor progression in humans. In canine mammary tumors, little information is available about this molecule. The aim of this study was to analyze, by immunohistochemistry, the be- havior of this molecule in canine mammary tumors with or without the presence of metastasis. The dogs were divided in groups without metastasis (G1) and with metastasis (G2, with subsets A—original neoplasia and B—metastatic neo- plasia). Tumors were classified according to the World Health Organization (WHO) criteria. The cells were counted whereby the plasma membrane and/or cytoplasm are stained. There was a significant increase in the number of cells immunostained for CD44 in the metastastic masses (G2B) as compared to groups G1 and G2A. It is concluded that in metastatic mass there was a significant increase in CD44 receptors, probably important for biology of the mammary tumor of dogs. Keywords: Dogs; Oncology; Mammary Tumors 1. Introduction The aim of this study is evaluate, by immunostaining, the comportament of CD44 receptor in malignant canine mammary neoplasias with and without metastasis in lymph node. CD44 is a multifunctional adhesion molecule that be- lo