Bitter Melon (Momordica Charantia) Reduces Serum Sialic Acid in Type2 Diabetics Evidence to Delay the Process of Atherosclerosis英文文献资料.docVIP

Chinese Medicine, 2011, 2, 125-129 125 doi:10.4236/cm.2011.24021 Published Online December 2011 (http://www.SciRP.org/journal/cm) Bitter Melon (Momordica Charantia) Reduces Serum Sialic Acid in Type2 Diabetics: Evidence to Delay the Process of Atherosclerosis Inayat Ur Rahman , Mohammad Bashir , Mohammad Salman , Mohammad Idrees , 1* 2 2 3 4 Mohammad Iqbal Khan 1 Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan Institute of Medical Science, Kohat University of Science Technology, Kohat, Pakistan Department of Pathology, Khyber Medical College, Peshawar, Pakistan Department of Chemistry, Kohat University of Science Technology, Kohat, Pakistan E-mail: marwax07@, mbashir@, dr_idrees@ Received February 7, 2011; revised April 3, 2011; accepted November 17, 2011 2 3 4 * Abstract More than 1000 herbal products have been used by diverse cultures of the world to treat hyperglycemia and among them bitter melon (Momordica charantia) is one of the most popular herbal resource. The beneficial effects of bitter melon is not limited to hypoglycaemia only, but it also ameliorates diet induced obesity, in- sulin resistance and exhibit cardioprotective effects. The present study attempts to investigate the effect of bitter melon fruit juice on a newly investigated risk factor, sialic acid in type2 diabetics. A total of 40 type2 diabetic patients, divided into group A (n = 20) and group B (n = 20) were investigated during the present study. The patients of group A were following bitter melon fruit juice treatment along with diet control, whereas the patients of group B were on diet control only. Serum sialic acid (SSA) decreased in group A from 66.20 ± 2.30 mg/dl to 63.50 ± 2.10 mg/dl (0.11) but, increased in group B from 66.50 ± 1.70 mg/dl to 68.20 ± 2.50 mg/dl (