BOLD-Perfusion Coupling during Monocular and Binocular Stimulation英文文献资料.docVIP

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BOLD-Perfusion Coupling during Monocular and Binocular Stimulation英文文献资料.doc

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BOLD-Perfusion Coupling during Monocular and Binocular Stimulation英文文献资料

HindawiPublishingCorporation InternationalJournalofBiomedicalImaging Volume2008,ArticleID628718,6pages doi:10.1155/2008/628718 ResearchArticle BOLD-PerfusionCouplingduringMonocularand BinocularStimulation ClaudineGauthier1,2andRichardD.Hoge1,2,3 1 2 3 Unit′edeNeuroimagerieFonctionnelle,InstitutUniversitairyofG′eriatriedeMontr′eal,Montreal,QC,CanadaH3W1W5 DepartmentofPhysiology,FacultyofMedicine,UniversityofMontreal,Montreal,QC,CanadaH3W1W5 InstituteofBiomedicalEngineering,FacultyofMedicine,UniversityofMontreal,Montreal,QC,CanadaH3W1W5 CorrespondenceshouldbeaddressedtoRichardD.Hoge,rhoge@umontreal.ca Received17October2007;Accepted29December2007 RecommendedbyOuryMonchi Previousstudieshavesuggestedthatduringselectiveactivationofasubsetofthezonescomprisingacolumnarsysteminvisual cortex,perfusionincreasesuniformlyinallcolumnsofthesystem,whileincreasesinoxidativemetabolismoccurpredominantly intheactivatedcolumns.Thiscouldleadtodisproportionatelylargebloodoxygenationlevel-dependent(BOLD)signalincreases foragiven?owincreaseduringmonocular(relativetobinocular)stimulation,duetocontributionsfromcolumnswhichundergo largeincreasesinperfusionwithlittleornochangeinoxidativemetabolism.Inthepresentstudy,wesoughttotestthishypoth- esisbymeasuringBOLD-perfusioncouplingratiosinspatiallyaveragedsignalsoverV1duringmonocularandbinocularvisual stimulation.Itwasfoundthat,althoughwithholdinginputtooneeyeresultedinstatisticallysigni?cantdecreasesinBOLDand perfusionsignalsinprimaryvisualcortex,theratiobetweenBOLDandperfusionincreasesdidnotchangesigni?cantly.These resultsdonotsupportagrossmismatchbetweenspatialpatternsof?owandmetabolismresponseduringmonocularstimulation. Copyright?2008C.GauthierandR.D.Hoge.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. 1. INTRODUCTION bylookingatthee?ectofselectiveactivationofonlypartofa small-scalecorticalcolumnarsystemo