Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women A 15-Year Population-Based Study英文文献资料.docVIP

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Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women A 15-Year Population-Based Study英文文献资料.doc

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Bone Loss Rate May Interact with Other Risk Factors for Fractures among Elderly Women A 15-Year Population-Based Study英文文献资料

SAGE-HindawiAccesstoResearch JournalofOsteoporosis Volume2010,ArticleID736391,10pages doi:10.4061/2010/736391 ResearchArticle BoneLossRateMayInteractwithOtherRiskFactorsforFractures amongElderlyWomen:A15-YearPopulation-BasedStudy JoonasSirola,1,2Anna-KaisaKoistinen,1KariSalovaara,1,2ToniRikkonen,1 MarjoTuppurainen,1,3JukkaS.Jurvelin,4 1 5 andHeikkiKr¨oger 1,2 RistoHonkanen, EskoAlhava, 1 2 3 4 5 BoneandCartilageResearchUnit(BCRU),UniversityofKuopio,70211Kuopio,Finland DepartmentofOrthopedicsandTraumatology,KuopioUniversityHospital,70211Kuopio,Finland DepartmentofObstetricsandGynaecology,KuopioUniversityHospital,70211Kuopio,Finland DepartmentofClinicalPhysiologyNuclearMedicine,KuopioUniversityHospital,70211Kuopio,Finland DepartmentofSurgery,KuopioUniversityHospital,70211Kuopio,Finland CorrespondenceshouldbeaddressedtoJoonasSirola,joonas.sirola@kuh.? Received8September2009;Revised15November2009;Accepted31December2009 AcademicEditor:SaekoFujiwara Copyright?2010JoonasSirolaetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Aimwastoinvestigatefracturerisk(FR)accordingtoboneloss(BL)rate.Arandomsampleof1652womenaged53.5yearswas measuredwithdualX-rayabsorptiometryinfemoralneckin1989and1994anddividedintotertilesofannualBLrate:high 0.84%,moderate0.13%–0.84%,andlow0.13%.Lowtraumaenergyfracturesduringfollowing10yearswererecorded.There werenodi?erencesinFRbetweenBLtertilesinCoxregressionmodel.FactorspredictinglowerFRinCoxmodelwereinhigh tertile:highT-score(HR0.71;95%CI0.54–0.93,P = .012),nosister’sfracture(HR0.35;0.19–0.64,P = .001),nomother’s fracture(HR0.52;0.31–0.88,P =.015),inmoderatetertile:highT-score(HR0.69;0.53–0.91,P =.008)andgoodgripstrength (HR0.98;0.97–0.99,P =.022).InlowtertiletherewerenopredictorsforFR.BLpredictedFRinwomenwithmother’sfracture inunivariateandmultivariatemodel(O