Bio-Inspired Microsystem for Robust Genetic Assay Recognition英文文献资料.docVIP

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Bio-Inspired Microsystem for Robust Genetic Assay Recognition英文文献资料.doc

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Bio-Inspired Microsystem for Robust Genetic Assay Recognition英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2008,ArticleID259174,10pages doi:10.1155/2008/259174 ResearchArticle Bio-InspiredMicrosystemforRobustGenetic AssayRecognition Jaw-ChyngLue1andWai-ChiFang2 1 2 DepartmentofElectricalEngineering-Electrophysics,UniversityofSouthernCalifornia,LosAngeles,CA90089,USA DepartmentofElectronicsEgineering,NationalChiaoTungUniversity,1001TaHsuehRoad,Hsinchu,Taiwan300,China CorrespondenceshouldbeaddressedtoJaw-ChyngLue,lormen@ Received14January2008;Accepted25March2008 RecommendedbyDanielHoward Acompact integrated system-on-chip(SoC)architecture solutionforrobust,real-time, and on-sitegeneticanalysis hasbeen proposed.Thismicrosystemsolutionisnoise-tolerableandsuitableforanalyzingtheweak?uorescencepatternsfromaPCR prepareddual-labeledDNAmicrochipassay.Inthearchitecture,aprecedingVLSIdi?erentiallogarithmmicrochipisdesignedfor e?ectivelycomputingthelogarithmofthenormalizedinput?uorescencesignals.AposteriorVLSIarti?cialneuralnetwork(ANN) processor chip is used for analyzing the processed signals from the di?erential logarithm stage. A single-channel logarithmic circuitwasfabricatedandcharacterized.AprototypeANNchipwithunsupervisedwinner-take-all(WTA)functionwasdesigned, fabricated,andtested.AnANNlearningalgorithmusinganovelsigmoid-logarithmictransferfunctionbasedonthesupervised backpropagation(BP)algorithmisproposedforrobustlyrecognizinglow-intensitypatterns.Ourresultsshowthatthetrained newANNcanrecognizelow-?uorescencepatternsbetterthananANNusingtheconventionalsigmoidfunction. Copyright?2008J.-C.LueandW.-C.Fang.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. 1. INTRODUCTION ouslypseudoisothermallyheatingmultiplezonesofaloop channelforPCRampli?cation[2].Thisthermocyclerdoes not contain the CE separation, the ?uorescence detection, andthedataanalysisfunctions.Theoretically