Bone Marrow Stem Cell Derived Paracrine Factors for Regenerative Medicine Current Perspectives and Therapeutic Potential英文文献资料.docVIP

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Bone Marrow Stem Cell Derived Paracrine Factors for Regenerative Medicine Current Perspectives and Therapeutic Potential英文文献资料.doc

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Bone Marrow Stem Cell Derived Paracrine Factors for Regenerative Medicine Current Perspectives and Therapeutic Potential英文文献资料

HindawiPublishingCorporation BoneMarrowResearch Volume2011,ArticleID207326,14pages doi:10.1155/2011/207326 ReviewArticle BoneMarrowStemCellDerivedParacrine FactorsforRegenerativeMedicine: CurrentPerspectivesandTherapeuticPotential TomJ.Burdon, ArghyaPaul, NicolasNoiseux, SatyaPrakash, 1 1 2 1 andDominiqueShum-Tim 3,4 1 2 3 4 BiomedicalTechnologyandCellTherapyResearchLaboratory,DepartmentofBiomedicalEngineering,FacultyofMedicine, Du?MedicalBuilding,3775UniversityStreet,McGillUniversity,QC,CanadaH3A2B4 D`epartmentdeChirurgieCardiaque,CentreHospitalierdel’Universit′edeMontr′eal,PavillonH?otel-Dieu, Universit′edeMontr′eal,Montr′eal,QC,CanadaH3C3J7 DivisionsofCardiacSurgeryandSurgicalResearch,TheMontrealGeneralHospital,McGillUniversityHealthCenter, QC,CanadaH3G1A4 TheRoyalVictoriaHospital,SuiteS8.73.B,687PineAvenueWest,Montr′eal,QC,CanadaH3A1A1 CorrespondenceshouldbeaddressedtoDominiqueShum-Tim,dshumtim@yahoo.ca Received31August2010;Accepted12October2010 AcademicEditor:HelenA.Papadaki Copyright?2011TomJ.Burdonetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Duringthepastseveralyears,therehasbeenintenseresearchinthe?eldofbonemarrow-derivedstemcell(BMSC)therapyto facilitateitstranslationintoclinicalsetting.Althoughalothasbeenaccomplished,plentyofchallengeslieahead.Furthermore, there is a growing body of evidence showing that administration of BMSC-derived conditioned media (BMSC-CM) can recapitulatethebene?ciale?ectsobservedafterstemcelltherapy.BMSCsproduceawiderangeofcytokinesandchemokinesthat have,untilnow,shownextensivetherapeuticpotential.Theseparacrinemechanismscouldbeasdiverseasstimulatingreceptor- mediatedsurvivalpathways,inducingstemcellhominganddi?erentiationorregulatingtheanti-in?ammatorye?ectsinwounded areas.Thecurrentreviewre?ectstherapidshiftofinterestfromBMSCtoBMSC-CMtoal