Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury英文文献资料.docVIP

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Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury英文文献资料.doc

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Bone Marrow Derivation of Interstitial Cells of Cajal in Small Intestine Following Intestinal Injury英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2010,ArticleID164986,9pages doi:10.1155/2010/164986 ResearchArticle BoneMarrowDerivationofInterstitialCellsofCajalin SmallIntestineFollowingIntestinalInjury DengqunLiu,FengchaoWang,ZhongminZou,ShiwuDong,JunpingWang,XinzeRan, ChunxueLi,ChunmengShi,andYongpingSu StateKeyLaboratoryofTrauma,BurnandCombinedInjury,InstituteofCombinedInjury,CollegeofPreventiveMedicine, ThirdMilitaryMedicalUniversity,Chongqing,400038,China CorrespondenceshouldbeaddressedtoYongpingSu,suyp2003@ Received1September2009;Revised24December2009;Accepted27January2010 AcademicEditor:RonnieGallagher Copyright?2010DengqunLiuetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. InterstitialcellsofCajal(ICCs)ingastrointestinaltract arespecializedcellsserving aspacemakercells.Theorigin ofICCsis currentlynotfullycharacterized.Inthiswork,weaimedtostudywhetherbonemarrow-derivedcells(BMDCs)couldcontribute to the origin of ICCs in the muscular plexus of small intestine using GFP-C57BL/6 chimeric mice.Engraftment of BMDCs in the intestine was investigated for GFP expression. GFP positive bone marrow mononuclear cells reached a proportion of 95.65%±3.72%atdi?erenttimesinchimerism.Donor-derivedcellsdistributedwidelyinallthelayersofthegastrointestinaltract. TherewereGFPpositiveBMDCsinthemyentericplexus,whichresembledcharacteristicsofICCs,includingmyentericlocation, c-Kitpositivestaining,andrami?edmorphology.Donor-derivedICCsinthemyentericplexuscontributedtoapercentageranging 9.25%± 4.9% of all the ICCs in the myenteric plexus. In conclusion, here we described that donor-derived BMDCs might di?erentiateintogastrointestinalICCsafterradiationinjury,whichprovidedanalternativesourcefortheoriginoftheICCsinthe muscularplexusofadultintestine.Theseresultsfurtheridenti?edtheplasticityofBMDCsandindicatedtherap