Can Biofluids Metabolic Profiling Help to Improve Healthcare during Pregnancy英文文献资料.docVIP

Hindawi Publishing Corporation Spectroscopy: An International Journal Volume 27 (2012), Issue 5-6, Pages 515–523 doi:10.1155/2012/128367 Can Bio?uids Metabolic Pro?ling Help to Improve Healthcare during Pregnancy? Gonc?alo Grac?a, Brian J. Goodfellow, Isabel M. Carreira, and Ana M. Gil 1 S′?lvia O. Diaz, 1 Joana Pinto, 1 Ant′onio S. Barros, Iola F. Duarte, 2 1 Maria do C′eu Almeida, 3 1 Eul′alia Galhano, 3 Cristina Pita, 3 4 1 1CICECODepartmentofChemistry,UniversityCampusofSantiago,UniversityofAveiro, 3810-193Aveiro,Portugal 2QOPNAResearchUnit,DepartmentofChemistry,UniversityCampusofSantiago, UniversityofAveiro,3810-193Aveiro,Portugal 3MaternidadeBissayaBarreto,CentroHospitalardeCoimbra,3000Coimbra,Portugal 4CytogeneticsandGenomicsLaboratory,FacultyofMedicine,UniversityofCoimbraand ForensicScienceCentre(CENCIFOR),Coimbra,Portugal Correspondence should be addressed to Ana M. Gil, agil@ua.pt Copyright ? 2012 Gonc?alo Grac?a et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract. This paper describes a metabonomics study of 2nd trimester bio?uids (amniotic ?uid, maternal urine, and blood plasma), in an attempt to correlate bio?uid metabolic changes with suspected/diagnosed fetal malformations (FM) and chromosomal disorders as well as with later occurring gestational diabetes mellitus (GDM), preterm delivery (PTD), and premature rupture of membranes (PROM). The global biochemical picture given by the threesome of bio?uids should enable the de?nition of potential disease signatures and unveil potential metabolite markers for clinical use in predictive prenatal diagnostics. Results show that relatively strong metabolic disturbances accompany FM, re?ected in all three bio?uids and thus suggesting the involvement of both fetal and maternal