Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo英文文献资料.docVIP

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Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo英文文献资料.doc

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Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2012,ArticleID506214,8pages doi:10.1155/2012/506214 ResearchArticle CardioprotectiveEffectsof20(S)-GinsenosideRh2against Doxorubicin-InducedCardiotoxicityInVitroandInVivo HongboWang, PengfeiYu, HaitaoGou, JianqiaoZhang, MeiZhu, Zhen-huaWang, 1 1 2 1 1 2 Jing-weiTian,1,2Yong-taoJiang,1,2andFeng-huaFu1 1 2 DepartmentofPharmacology,SchoolofPharmacy,YantaiUniversity,Yantai264005,China StateKeyLaboratoryofLong-ActingandTargetingDrugDeliveryTechnologies,LuyePharmaGroupLtd.,Yantai264003,China CorrespondenceshouldbeaddressedtoFeng-huaFu,fufenghua@ Received27May2012;Revised23August2012;Accepted13September2012 AcademicEditor:Seung-HeonHong Copyright?2012HongboWangetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Doxorubicin(DOX)isconsideredasoneofthebestantineoplasticagents.However,itsclinicaluseisrestrictedbyitsassociated cardiotoxicity,whichismediatedbytheproductionofreactiveoxygenspecies.Inthisstudy,20(S)-ginsenosideRh2(Rh2)was exploredwhetherithadprotectivee?ectsagainstDOX-inducedcardiotoxicity.Invitro studyonH9C2cellline,aswellasin vivoinvestigationinonemouseandoneratmodelofDOX-inducedcardiomyopathy,wascarriedout.Theresultsshowedthat pretreatmentwithRh2signi?cantlyincreasedtheviabilityofDOX-injuredH9C2cells.Inthemousemodel,Rh2couldsuppress theDOX-inducedreleaseofthecardiacenzymesintoserumandimprovedtheoccurredpathologicalchangesthroughameliorating thedecreasedantioxidantbiomoleculesandthecumulatedlipidperoxidationmalondialdehydeinhearttissues.Intheratmodel, Rh2couldattenuatethechangeofECGresultingfromDOXadministration.Furthermore,Rh2enhancedtheantitumoractivity ofDOXinA549cells.Our?ndingsthusdemonstratedthatRh2pretreatmentcoulde?ectivelyalleviateheartinjuryinducedby DOX,andRh