Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection A Preliminary Study with MicroPET英文文献资料.docVIP

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Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection A Preliminary Study with MicroPET英文文献资料.doc

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Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F-FDG Injection A Preliminary Study with MicroPET英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2011,ArticleID159834,5pages doi:10.1155/2011/159834 ResearchArticle BrownAdiposeTissueCanBeActivatedor InhibitedwithinanHourbefore18F-FDGInjection: APreliminaryStudywithMicroPET ChenxiWu,WuyingCheng,HaiqunXing,YonghongDang,FangLi,andZhaohuiZhu DepartmentofNuclearMedicine,PekingUnionMedicalCollegeHospital, ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100730,China CorrespondenceshouldbeaddressedtoZhaohuiZhu,zzh1969@ Received30December2010;Accepted16February2011 AcademicEditor:MeiTian Copyright?2011ChenxiWuetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Brownadiposetissue(BAT)isemergingasapotentialtargetfortreatinghumanobesity.IthasbeenindicatedthatBATisrichin innervationsofsympatheticnervecontrol.Using 18 F-FDGmicroPETimaging,thisstudyaimsatevaluatinghowfactorsrelated F-FDGuptakeweresemiquantitativelyevaluated tosympatheticactivation/inhibitionchangedBATmetabolismofmice.BAT 18 in di?erent groups of mice under temperature (cold or warm stimulus) or pharmacological interventions (norepinephrine, epinephrine,isoprenaline,orpropranolol)andwerecomparedwiththecorrespondingcontrols.ItwasfoundthatBATactivation canbestimulatedbycoldexposure(P=1.96×10?4),norepinephrine(P=.002),orboth(P=2.19×10?6)withinanhourbefore 18 F-FDGinjectionandcanalsobealleviatedbywarmingup(P=.001)orpropranolollavage(P=.027).Thispreliminarystudy 18 F-FDGPETimagingthroughshort-terminterventions,whichpavedtheway indicatedthatBATfunctioncouldbeevaluatedby forfurtherinvestigationoftherelationshipbetweenhumanobesityandBATdysfunction. 1.Introduction body weight, using, for instance, β3-adrenoceptor agonists CL-316243orL-796568[7,8].Butnoneofthemmonitored BATmetabolicfunctionduringtheirresearches. Cold stimulus has been proved to increase 18F-FDG Brownadiposetissue(BAT)isakin