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Cells in Dengue Virus Infection In Vivo英文文献资料
HindawiPublishingCorporation
AdvancesinVirology
Volume2010,ArticleID164878,15pages
doi:10.1155/2010/164878
ReviewArticle
CellsinDengueVirusInfectionInVivo
Hui-MienHsiao,
SansaneeNoisakran,1,2NattawatOnlamoon,1,3PuchareeSongprakhon,3 1
4 1
KulkanyaChokephaibulkit, andGueyChuenPerng
1
DepartmentofPathologyandLaboratoryMedicine,DentalSchoolBuilding,EmoryVaccineCenter,EmoryUniversitySchoolof
Medicine,1462CliftonRoad,Atlanta,GA30322,USA
2
MedicalBiotechnologyUnit,NationalCenterforGeneticEngineeringandBiotechnology,NationalScienceandTechnology
DevelopmentAgency,Pathumthani12120,Thailand
3
4
O?ceforResearchandDevelopment,FacultyofMedicineSirirajHospital,MahidolUniversity,Bangkok10700,Thailand
DepartmentofPediatrics,SirirajHospital,MahidolUniversity,Bangkok10700,Thailand
CorrespondenceshouldbeaddressedtoGueyChuenPerng,gperng@
Received9March2010;Accepted6July2010
AcademicEditor:EricO.Freed
Copyright?2010SansaneeNoisakranetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
Denguehasbeenrecognizedasoneofthemostimportantvector-borneemerginginfectiousdiseasesglobally.Thoughdengue
normally causes a self-limiting infection, some patients may develop a life-threatening illness, dengue hemorrhagic fever
(DHF)/dengueshocksyndrome(DSS).ThereasonwhyDHF/DSSoccursincertainindividualsisunclear.Studiesintheendemic
regionssuggestthatthepreexistingantibodiesareariskfactorforDHF/DSS.Viremiaandthrombocytopeniaarethekeyclinical
featuresofdenguevirusinfectioninpatients.Theamountsofviruscirculatinginpatientsarehighlycorrelatedwithseveredengue
disease,DHF/DSS.Also,thedisturbance,mainlyatransientdepression,ofhematologicalcellsisacriticalclinical?ndinginacute
denguepatients.However,thecellsresponsibleforthedengueviremiaareunresolvedinspiteoftheintensivee?ortsbeenmade.
Denguevirusappearstoreplicateandproliferateinma
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