Diva Reduces Cell Death in Response to Oxidative Stress and Cytotoxicity 英文参考文献.docVIP

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Diva Reduces Cell Death in Response to Oxidative Stress and Cytotoxicity 英文参考文献.doc

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Diva Reduces Cell Death in Response to Oxidative Stress and Cytotoxicity 英文参考文献

DivaReducesCellDeathinResponsetoOxidativeStress andCytotoxicity NicoleSuyunLiu1,XiaoliDu2,JiaLu1,3,BeiPingHe1* 1DepartmentofAnatomy,YongLooLinSchoolofMedicine,NationalUniversityofSingapore,Singapore,Singapore,2Duke-NUSGraduateMedicalSchoolSingapore, Singapore,Singapore,3DefenceMedicalandEnvironmentalResearchInstitute,DSONationalLaboratories,Singapore,Singapore Abstract DivaisamemberoftheBcl2familybutitsfunctioninapoptosisremainslargelyunclearbecauseofitsspecificexpression foundwithinlimitedadulttissues.Previousoverexpressionstudiesdoneonvariouscelllinesyieldedconflictingconclusions pertainingtoitsapoptoticfunction.Here,wediscoveredtheexpressionofendogenousDivainPC12neuronal-likecellline andratbonemarrowmesenchymalstemcells(BMSCs),leadingtotheirutilisationforthefunctionalstudyofDiva.Through usage of recombinant Fas ligand, hydrogen peroxide, overexpression and knock down experiments, we discovered that Divaplaysacrucialpro-survivalrolevia themitochondrialdeath pathway.Inaddition,immunoprecipitation studiesalso notedadecreaseinDiva’sinteractionwithBcl2andBaxfollowingapoptosisinducedbyoxidativestress.Byoverexpressing DivainBMSCs,wehadobservedanincreaseinthecells’capacitytosurviveunderoxidativestressandmicroglialtoxicity. TheresultobtainedfromourstudygivesusreasontobelievethatDivaplaysanimportantroleincontrollingthesurvivalof BMSCs.ThroughoverexpressionofDiva,theviabilityoftheseBMSCsmaybeboostedunderadverseconditions. Citation: Liu NS, Du X, Lu J, He BP (2012) Diva Reduces Cell Death in Response to Oxidative Stress and Cytotoxicity. PLoS ONE 7(8): e43180. doi:10.1371/ journal.pone.0043180 Editor:AlexanderJamesRoyBishop,UniversityofTexasHealthScienceCenteratSanAntonio,UnitedStatesofAmerica ReceivedJanuary10,2012;AcceptedJuly20,2012;PublishedAugust15,2012 Copyright:?2012Liuetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsour