Evaluation of Different Biomarkers to Predict Individual Radiosensitivity in an Inter-Laboratory Comparison–Lessons for Future Studies 英文参考文献.docVIP

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Evaluation of Different Biomarkers to Predict Individual Radiosensitivity in an Inter-Laboratory Comparison–Lessons for Future Studies 英文参考文献.doc

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Evaluation of Different Biomarkers to Predict Individual Radiosensitivity in an Inter-Laboratory Comparison–Lessons for Future Studies 英文参考文献

EvaluationofDifferentBiomarkerstoPredictIndividual RadiosensitivityinanInter-LaboratoryComparison– LessonsforFutureStudies BurkhardGreve1*,TobiasBo¨lling1,SusanneAmler4,UteRo¨ssler8,MariaGomolka8,ClaudiaMayer7, OdiliaPopanda7,KristinDreffke2¤a,AstridRickinger3,EberhardFritz2¤b,FriederikeEckardt-Schupp3, ChristinaSauerland4,HerbertBraselmann5,WiebkeSauter6,ThomasIllig6,DorotheaRiesenbeck1¤c, StefanKo¨nemann1¤d,NormannWillich1,SimoneMo¨rtl3,HansTheodorEich1,PeterSchmezer7 1DepartmentofRadiotherapy,UniversityHospitalofMuenster,Muenster,Germany,2LeibnizInstituteforAgeResearch–FritzLipmannInstitute(FLI),Jena,Germany, 3Institute of Radiation Biology, Helmholtz Centre Munich – German Research Centre for Environmental Health, Neuherberg, Germany, 4Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany, 5Institute of Molecular Radiation Biology, Helmholtz Centre Munich – German Research Centre for EnvironmentalHealth,Neuherberg,Germany,6InstituteofEpidemiology,HelmholtzCentreMunich–GermanResearchCentreforEnvironmentalHealth,Neuherberg, Germany,7Division ofEpigenomicsand CancerRiskFactors,German CancerResearchCentre (DKFZ), Heidelberg, Germany, 8Federal Officefor Radiation Protection, DepartmentofRadiationProtectionandHealth,Oberschleissheim,Germany Abstract Radiotherapyisapowerfulcureforseveraltypesofsolidtumours,butitsapplicationisoftenlimitedbecauseofsevereside effectsinindividualpatients.Withtheaimtofindbiomarkerscapableofpredictingnormaltissuesidereactionsweanalysed the radiation responses of cells from individual head and neck tumour and breast cancer patients of different clinical radiosensitivityinamulticentricstudy.Multipleparametersofcellularradiosensitivitywereanalysedincodedsamplesof peripheral blood lymphocytes (PBLs) and derived lymphoblastoid cell lines (LCLs) from 15 clinical radio-hypersensitive tumourpatients and comparedtoage- andsex-matchednon-radiosensitive patientcontrolsand15 lymphoblastoid cell linesfromage-