Evidence of Increased Muscle Atrophy and Impaired Quality of Life Parameters in Patients with Uremic Restless Legs Syndrome 英文参考文献.docVIP

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Evidence of Increased Muscle Atrophy and Impaired Quality of Life Parameters in Patients with Uremic Restless Legs Syndrome 英文参考文献.doc

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Evidence of Increased Muscle Atrophy and Impaired Quality of Life Parameters in Patients with Uremic Restless Legs Syndrome 英文参考文献

EvidenceofIncreasedMuscleAtrophyandImpaired QualityofLifeParametersinPatientswithUremic RestlessLegsSyndrome ChristoforosD.Giannaki1,6,8,GiorgosK.Sakkas1,6*,ChristinaKaratzaferi5,6,GeorgiosM. Hadjigeorgiou2,6,EleftheriosLavdas4,VassiliosLiakopoulos1,NikolaosTsianas7,GeorgiosN. Koukoulis3,YiannisKoutedakis5,6,IoannisStefanidis1,6 1DepartmentofNephrology,UniversityofThessaly,Larissa,Thessaly,Greece,2DepartmentofNeurology,UniversityofThessaly,Larissa,Thessaly,Greece,3Department ofEndocrinology,SchoolofMedicine,UniversityofThessaly,Larissa,Thessaly,Greece,4DepartmentofMedicalRadiologicalTechnologists,TechnologicalEducational Institute of Athens, Athens, Attika, Greece, 5Department of Sport Science, University of Thessaly, Trikala, Thessaly, Greece, 6Centre for Research and Technology – Thessaly,Volos,Thessaly,Greece,7DepartmentofNephrology,GeneralHospitalofTrikala,Trikala,ThessalyGreece,8DepartmentofLifeandHealthSciences,University ofNicosia,Nicosia,Cyprus Abstract Background: Restless Legs Syndrome is a very common disorder in hemodialysis patients. Restless Legs Syndrome negativelyaffectsqualityoflife;howeveritisnotclearwhetherthisisduetomentalorphysicalparametersandwhetheran associationexistsbetweenthesyndromeandparametersaffectingsurvival. Methodology/PrincipalFindings:UsingtheRestlessLegsSyndromecriteriaandthepresenceofPeriodicLimbMovements inSleep(PLMS/h.15),70clinicallystablehemodialysispatientswereassessedanddividedintotheRLS(n=30)andnon- RLS (n=40) groups. Physical performance was evaluated by a battery of tests: body composition by dual energy X ray absorptiometry,musclesizeandcompositionbycomputertomography,whiledepressionsymptoms,perceptionofsleep qualityandqualityoflife wereassessed through validatedquestionnaires.Inthis crosssectionalanalysis,theRLSgroup showedevidenceofthighmuscleatrophycomparedtothenon-RLSgroup.Sleepqualityanddepressionscorewerefound to be significantly impaired in the RLS group. The mental component of the quality of life questionn