Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm-Specific Ion Channel Complex CatSpers and CatSperβ 英文参考文献.docVIP

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Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm-Specific Ion Channel Complex CatSpers and CatSperβ 英文参考文献.doc

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Evolutionary Genomics Reveals Lineage-Specific Gene Loss and Rapid Evolution of a Sperm-Specific Ion Channel Complex CatSpers and CatSperβ 英文参考文献

EvolutionaryGenomicsRevealsLineage-SpecificGene LossandRapidEvolutionofaSperm-SpecificIon ChannelComplex:CatSpersandCatSperb XinjiangCai1,2*,DavidE.Clapham3 1DepartmentofCellBiology,DukeUniversityMedicalCenter,Durham,NorthCarolina,UnitedStatesofAmerica,2DepartmentofMedicine(Cardiology),DukeUniversity MedicalCenter,Durham,NorthCarolina,UnitedStatesofAmerica,3HowardHughesMedicalInstitute,DepartmentofCardiology,Children’sHospital,andDepartmentof Neurobiology,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica Abstract ThemammalianCatSperionchannelfamilyconsistsoffoursperm-specificvoltage-gatedCa2+channelsthatarecrucialfor spermhyperactivationandmalefertility.AllfourCatSpersubunitsarebelievedtoassembleintoaheteromultimericchannel complex,togetherwithanauxiliarysubunit,CatSperb.Here,wereportacomprehensivecomparativegenomicsstudyand evolutionary analysis of CatSpers and CatSperb, with important correlation to physiological significance of molecular evolution of the CatSper channel complex. The development of the CatSper channel complex with four CatSpers and CatSperboriginatedasearlyasprimitivemetazoanssuchastheCnidarianNematostellavectensis.Comparativegenomics revealedextensivelineage-specificgenelossofallfourCatSpersandCatSperbthroughmetazoanevolution,especiallyin vertebrates.TheCatSperchannelcomplexunderwentrapidevolutionandfunctionaldivergence,whiledistinctevolutionary constraints appear to have acted on different domains and specific sites of the four CatSper genes. These results reveal unique evolutionary characteristics of sperm-specific Ca2+ channels and their adaptation to sperm biology through metazoanevolution. Citation:CaiX,ClaphamDE(2008)EvolutionaryGenomicsRevealsLineage-SpecificGeneLossandRapidEvolutionofaSperm-SpecificIonChannelComplex: CatSpersandCatSperb.PLoSONE3(10):e3569.doi:10.1371/journal.pone.0003569 Editor:ArnoldSchwartz,UniversityofCincinnati,UnitedStatesofAmerica ReceivedSeptember3,2008;AcceptedOctober9,2008;PublishedOctober30,2008