Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control 英文参考文献.docVIP

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Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control 英文参考文献.doc

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Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control 英文参考文献

FenechGenomeIntegrity2010,1:11 /content/1/1/11 GENOME INTEGRITY REVIEW OpenAccess Nutriomesandnutrientarrays-thekeyto personalisednutritionforDNAdamage preventionandcancergrowthcontrol MichaelFFenech Abstract DNAdamageatthebase-sequence,epigenomeandchromosomelevelisafundamentalcauseofdevelopmental anddegenerativediseases.Multiplemicronutrientsandtheirinteractionswiththeinheritedand/oracquiredgen- omedetermineDNAdamageandgenomicinstabilityrates.Thechallengeistoidentifyforeachindividualthe combinationofmicronutrientsandtheirdoses(i.e.thenutriome)thatoptimisesgenomestabilityandDNArepair. InthispaperIdescribeandproposetheuseofhigh-throughputnutrientarraysystemswithhighcontentanalysis diagnosticsofDNAdamage,celldeathandcellgrowthfordefining,onanindividualbasis,theoptimalnutriome forDNAdamagepreventionandcancergrowthcontrol. BackgroundandCurrentStatus term culture of cells (e.g. stem cells) which may be DNA damage at the base sequence, epigenome and takenoutofthebody forexpansion andthenreturned chromosome level is the most fundamental cause of to the original donor or other recipients for medical developmental and degenerative diseases (including therapy reasons because DNA damage accumulated accelerated ageing) and is predictive prospectively of in vitro may result in oncogenic events in stem cells these conditions [1-3]. Hundreds of genes are involved [29,30]. Currently dietary reference values (e.g. recom- in maintenance of genome integrity and there is great mended daily intakes, upper safety limits) and culture variation amongst individuals with respect to common mediumrecipesandconditionsdonottakeintoconsid- polymorphisms that impact on the activity of these erationimpactongenomeintegrityandyetharmtothe enzymes [4-8]. The proteins encoded by those genes DNA sequence and/or the epigenome is the most fun- requiredforDNAreplication,DNArepairordetoxifica- damentalandcritical pathologyunderlyingcellular and tion ofpotential genotoxins depend onessen