Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese 英文参考文献.docVIP

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Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese 英文参考文献.doc

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Reproducibility, Performance, and Clinical Utility of a Genetic Risk Prediction Model for Prostate Cancer in Japanese 英文参考文献

Reproducibility,Performance,andClinicalUtilityofa GeneticRiskPredictionModelforProstateCancerin Japanese ShusukeAkamatsu1,2,AtsushiTakahashi3,RyoTakata1,4,MichiakiKubo5,TakahiroInoue2, TakashiMorizono6,TatsuhikoTsunoda6,NaoyukiKamatani3,ChristopherA.Haiman7,PeggyWan7, GaryK.Chen7,LoicLeMarchand8,LaurenceN.Kolonel8,BrianE.Henderson7,TomoakiFujioka3, TomonoriHabuchi9,YusukeNakamura10,OsamuOgawa2,HidewakiNakagawa1* 1LaboratoryforBiomarkerDevelopment,CenterforGenomicMedicine,RIKEN,Tokyo,Japan,2DepartmentofUrology,GraduateSchoolofMedicine,KyotoUniversity, Kyoto,Japan,3LaboratoryforStatisticalAnalysis,CenterforGenomicMedicine,RIKEN,Tokyo,Japan,4DepartmentofUrology,IwateMedicalUniversity,Morioka,Japan, 5LaboratoryforGenotypingDevelopment,CenterforGenomicMedicine,RIKEN,Yokohama,Japan,6LaboratoryforMedicalInformatics,CenterforGenomicMedicine, RIKEN, Yokohama, Japan, 7Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America,8EpidemiologyProgram,CancerResearchCentre,UniversityofHawaii,Honolulu,Hawaii,UnitedStatesofAmerica,9DepartmentofUrology,AkitaUniversity SchoolofMedicine,Akita,Japan,10LaboratoryofMolecularMedicine,HumanGenomeCenter,InstituteofMedicalScience,theUniversityofTokyo,Tokyo,Japan Abstract Prostatespecificantigen(PSA)iswidelyusedasadiagnosticbiomarkerforprostatecancer(PC).However,duetoitslow predictive performance, many patients without PC suffer from the harms of unnecessary prostate needle biopsies. The present study aims to evaluate the reproducibility and performance of a genetic risk prediction model in Japanese and estimateitsutilityasadiagnosticbiomarkerinaclinicalscenario.Wecreatedalogisticregressionmodelincorporating16 SNPsthatweresignificantlyassociatedwithPCinagenome-wideassociationstudyofJapanesepopulationusing689cases and749malecontrols.ThemodelwasvalidatedbytwoindependentsetsofJapanesesamplescomprising3,294casesand 6,281malecontrols.Theareasundercurve(AUC)ofthem