Retinal Spectral Domain Optical Coherence Tomography in Early Atrophic Age-Related Macular Degeneration (AMD) and a New Metric for Objective Evaluation of the Efficacy of Ocular Nutrition 英文参考文献.docVIP

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Retinal Spectral Domain Optical Coherence Tomography in Early Atrophic Age-Related Macular Degeneration (AMD) and a New Metric for Objective Evaluation of the Efficacy of Ocular Nutrition 英文参考文献.doc

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Retinal Spectral Domain Optical Coherence Tomography in Early Atrophic Age-Related Macular Degeneration (AMD) and a New Metric for Objective Evaluation of the Efficacy of Ocular Nutrition 英文参考文献

Nutrients 2012, 4, 1812-1827; doi:10.3390/nu4121812 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Article Retinal Spectral Domain Optical Coherence Tomography in Early Atrophic Age-Related Macular Degeneration (AMD) and a New Metric for Objective Evaluation of the Efficacy of Ocular Nutrition Stuart Richer 1,2,*, Jane Cho 1,2, William Stiles 1, Marc Levin 1, James S. Wrobel 3, Michael Sinai 4 and Carla Thomas 1 1 Eye Clinic, James A Lovell Federal Health Care Center, North Chicago, IL 60064, USA; E-Mails: jane.cho@ (J.C.); ilovemabel@ (W.S.); medpat@ (M.L.); carla.thomas2@ (C.T.) 2 Family Preventive Medicine, RFUMS Chicago Medical School, North Chicago, IL 60064, USA 3 Internal Medicine, Podiatry Services, University of Michigan, Ann Arbor, MI 48105, USA; E-Mail: jswrobel@ 4 Optovue Inc., Fremont, CA 94538, USA; E-Mail: mike_sinai@ * Author to whom correspondence should be addressed; E-Mail: Stuart.Richer1@VA.Gov; Tel.: +1-224-610-7145. Received: 11 October 2012; in revised form: 12 November 2012 / Accepted: 14 November 2012 / Published: 27 November 2012 Abstract: Purpose: A challenge in ocular preventive medicine is identification of patients with early pathological retinal damage that might benefit from nutritional intervention. The purpose of this study is to evaluate retinal thinning (RT) in early atrophic age-related macular degeneration (AMD) against visual function data from the Zeaxanthin and Visual Function (ZVF) randomized double masked placebo controlled clinical trial (FDA IND #78973). Methods: Retrospective, observational case series of medical center veterans with minimal visible AMD retinopathy (AREDS Report #18 simplified grading 1.4/4.0 bilateral retinopathy). Foveal and extra-foveal four quadrant SDOCT RT measurements were evaluated in n = 54 clinical and ZVF AMD patients. RT by age was determined and compared to the OptoVue SD OCT normativ