Patterns of Genome Evolution among the Microsporidian Parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi 英文参考文献.docVIP

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Patterns of Genome Evolution among the Microsporidian Parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi 英文参考文献.doc

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Patterns of Genome Evolution among the Microsporidian Parasites Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon bieneusi 英文参考文献

PatternsofGenomeEvolutionamongtheMicrosporidian ParasitesEncephalitozooncuniculi,Antonospora locustaeandEnterocytozoonbieneusi NicolasCorradi1.,DonnaE.Akiyoshi2.,HilaryG.Morrison3,XiaochuanFeng2,LouisM.Weiss4,SaulTzipori2,PatrickJ.Keeling1* 1DepartmentofBotany,CanadianInstituteforAdvancedResearch,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada,2Divisionof Infectious Diseases, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America, 3Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, Massachusetts, United States of America, 4DepartmentofMedicine,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica Background. Microsporidia are intracellular parasites that are highly-derived relatives of fungi. They have compacted genomes and, despite a high rate of sequence evolution, distantly related species can share high levels of gene order conservation. To date, only two species have been analysed in detail, and data from one of these largely consists of short genomic fragments. It is therefore difficult to determine how conservation has been maintained through microsporidian evolution,andimpossibletoidentifywhethercertainregionsaremorepronetogenomicstasis.PrincipalFindings.Here,we analysethreelargefragmentsoftheEnterocytozoonbieneusigenome(intotal429kbp),aspeciesofmedicalsignificance.A total of 296 ORFs were identified, annotated and their context compared with Encephalitozoon cuniculi and Antonospora locustae. Overall, a high degree of conservation was found between all three species, and interestingly the level of conservation was similar in all three pairwise comparisons, despite the fact that A. locustae is more distantly related to E. cuniculiandE.bieneusithaneitheraretoeachother.Conclusions/Significance.Anytwogenesthatarefoundtogetherin anypairofgenomesaremorelikelytobeconservedinthethirdgenomeaswell,suggestingthatacoreofgenestendst