Satiating Capacity and Post-Prandial Relationships between Appetite Parameters and Gut-Peptide Concentrations with Solid and Liquefied Carbohydrate 英文参考文献.docVIP

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Satiating Capacity and Post-Prandial Relationships between Appetite Parameters and Gut-Peptide Concentrations with Solid and Liquefied Carbohydrate 英文参考文献.doc

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Satiating Capacity and Post-Prandial Relationships between Appetite Parameters and Gut-Peptide Concentrations with Solid and Liquefied Carbohydrate 英文参考文献

SatiatingCapacityandPost-PrandialRelationships betweenAppetiteParametersandGut-Peptide ConcentrationswithSolidandLiquefiedCarbohydrate MiekeJ.I.Martens1,2*,SofieG.T.Lemmens1,2,JurriaanM.Born1,2,MargrietS.Westerterp-Plantenga1,2 1NUTRIMSchoolforNutrition,ToxicologyandMetabolism,MaastrichtUniversityMedicalCentre+(MUMC+),DepartmentofHumanBiology,Maastricht,TheNetherlands, 2TopInstituteFoodandNutrition,Wageningen,TheNetherlands Abstract Background:Differencesinsatiatingcapacityofliquidandsolidmealsareunclear. Objective: Investigating appetite parameters, physiological measurements and within-subject relationships after consumption of a single macronutrient, subject-specific carbohydrate meal in liquefied versus solid form, controlled for energydensity,weightandvolume. Design: Inacross-over design, tenmalesubjects (age=21.163.9y, BMI=22.461.2kg/m2) consumed asolid (CS,whole peaches +750ml water)andliquefiedcarbohydrate (CL,peach blendedin 500mlwater +250mlwater)lunch. Appetite profiles,insulin-,glucose-andghrelinconcentrationsweremeasuredoverthreehours.Post-prandialrelationshipsbetween appetiteandbloodparameterswerecalculatedusingsubject-specificregressionanalyses. Results:FullnessratingswerehigherintheCL(8565mm)comparedtotheCScondition(7368mm)at20min(p,0.03). Glucoseconcentrationspeaked20to30minafterthestartofthelunchintheCLcondition,and30to40minafterstartof theCScondition.Correspondingly,insulinconcentrationswerepeakedat20–30minintheCLcondition,andat30–40min intheCScondition.AUCorconditionxtimeinteractionswerenotdifferentcomparingtheCLandtheCScondition.Insulin wassignificantlyhigherintheCScomparedtotheCLcondition40minafterthestartofthelunch(p,0.05).Fullnessscores weresignificantlyrelatedtoinsulinconcentrationsbutnottoglucoseconcentrations;desiretoeatscoresweresignificantly associatedwithghrelinconcentrationsinboth,theCLandtheCScondition.Therelationshipbetweenfullnessscoresand glucoseconcentrationswasnotstatisticallysignificant. Conclusion:Liquefiedandsolidcarbo