Sedation in the intensive care unit with remifentanilpropofol versus midazolamfentanyl a randomised, open-label, pharmacoeconomic trial 英文参考文献.docVIP

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Sedation in the intensive care unit with remifentanilpropofol versus midazolamfentanyl a randomised, open-label, pharmacoeconomic trial 英文参考文献.doc

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Sedation in the intensive care unit with remifentanilpropofol versus midazolamfentanyl a randomised, open-label, pharmacoeconomic trial 英文参考文献

Available online /content/10/3/R91 Research Open Access Vol 10 No 3 Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label, pharmacoeconomic trial Bernd Muellejans1, Thomas Matthey1, Joachim Scholpp2 and Markus Schill2 1Department of Anaesthesiology and Intensive Care Medicine, Heart Centre Mecklenburg-Vorpommern, Germany 2Medical Department, GlaxoSmithKline, Munich, Germany Corresponding author: Bernd Muellejans, dr.muellejans@drguth.de Received: 26 Jan 2006 Revisions requested: 14 Feb 2006 Revisions received: 8 Mar 2006 Accepted: 8 May 2006 Published: 15 Jun 2006 Critical Care 2006, 10:R91 (doi:10.1186/cc4939) This article is online at: /content/10/3/R91 ? 2006 Muellejans et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction Remifentanil is an opioid with a unique supplemented only in the case of insufficient sedation at pharmacokinetic profile. Its organ-independent elimination and short context-sensitive half time of 3 to 4 minutes lead to a highly predictable offset of action. We tested the hypothesis that with an analgesia-based sedation regimen with remifentanil and propofol, patients after cardiac surgery reach predefined criteria for discharge from the intensive care unit (ICU) sooner, resulting in shorter duration of time spent in the ICU, compared to a conventional regimen consisting of midazolam and fentanyl. In addition, the two regimens were compared regarding their costs. maximal remifentanil dose. Patients in the midazolam/fentanyl group received midazolam (0.02 to 0.2 mg kg-1 h-1) and fentanyl (1.0 to 7.0 μg kg-1 h-1). For treatment of pain after extubation, both groups received morphine and/or non