Species Difference of CD137 Ligand Signaling in Human and Murine Monocytes 英文参考文献.docVIP

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Species Difference of CD137 Ligand Signaling in Human and Murine Monocytes 英文参考文献.doc

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Species Difference of CD137 Ligand Signaling in Human and Murine Monocytes 英文参考文献

SpeciesDifferenceofCD137LigandSignalinginHuman andMurineMonocytes QianqiaoTang1,2,DongshengJiang1,ZheShao1,JuliaM.Mart?′nezGo′mez1,HerbertSchwarz1,2* 1DepartmentofPhysiology,andImmunologyProgramme,YongLooLinSchoolofMedicine,NationalUniversityofSingapore,Singapore,Singapore,2NUSGraduate SchoolforIntegrativeSciencesandEngineering,NationalUniversityofSingapore,Singapore,Singapore Abstract Background:StimulationofCD137ligandonhumanmonocyteshasbeenshowntoinduceDCdifferentiation,andthese CD137L-DCsaremorepotentthanclassicalDCs,instimulatingTcellresponsesinvitro.Toallowaninvivoevaluationofthe potencyofCD137L-DCsinmurinemodelsweaimedatgeneratingmurineCD137L-DCs. Methodology/Principal Findings: When stimulated through CD137 ligand murine monocytes responded just as human monocyteswithanincreasedadherence,morphologicalchanges,proliferationandanincreaseinviablecellnumbers.But CD137 ligand signaling did not induce expression of inflammatory cytokines and costimulatory molecules in murine monocytesandthesecellshadnoTcellstimulatoryactivity.MurinemonocytesdidnotdifferentiatetoinflammatoryDCs uponCD137ligandsignaling.Furthermore,whileCD137ligandsignalinginducesmaturationofhumanimmatureclassical DCsitfailedtodosowithmurineimmatureclassicalDCs. Conclusions/Significance:ThesedatademonstratethatbothhumanandmurinemonocytesbecomeactivatedbyCD137 ligandsignalingbutonlyhumanandnotmurinemonocytesdifferentiatetoinflammatoryDCs. Citation:TangQ,JiangD,ShaoZ,Mart?′nezGo′mezJM,SchwarzH(2011)SpeciesDifferenceofCD137LigandSignalinginHumanandMurineMonocytes.PLoS ONE6(1):e16129.doi:10.1371/journal.pone.0016129 Editor:RafaelLinden,UniversidadeFederaldoRiodeJaneiro,Brazil ReceivedAugust6,2010;AcceptedDecember12,2010;PublishedJanuary14,2011 Copyright: ? 2011 Tang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:This