Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm Is Regulated by Notch Signaling 英文参考文献.docVIP

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Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm Is Regulated by Notch Signaling 英文参考文献.doc

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Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm Is Regulated by Notch Signaling 英文参考文献

SpecificationofDrosophilaCorporaCardiaca NeuroendocrineCellsfromMesodermIsRegulatedby NotchSignaling SangbinPark1,ErikaL.Bustamante1,JulieAntonova1,GraemeW.McLean1,2,SeungK.Kim1,2,3 * 1Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America, 2Howard Hughes Medical Institute, Stanford,California,UnitedStatesofAmerica,3DepartmentofMedicine(Oncology),StanfordUniversitySchoolofMedicine,Stanford,California,UnitedStatesofAmerica Abstract Drosophila neuroendocrine cells comprising the corpora cardiaca (CC) are essential for systemic glucose regulation and represent functional orthologues of vertebrate pancreatic a-cells. Although Drosophila CC cells have been regarded as developmental orthologues of pituitary gland, the genetic regulation of CC development is poorly understood. From a geneticscreen,weidentifiedmultiplenovelregulatorsofCCdevelopment,includingNotchsignalingfactors.Ourstudies demonstrate that the disruption of Notch signaling can lead to the expansion of CC cells. Live imaging demonstrates localizedemergenceofextraprecursorcellsasthebasisofCCexpansioninNotchmutants.Contrarytoarecentreport,we unexpectedlyfoundthatCCcellsoriginatefromheadmesoderm.WeshowthatTinmanexpressioninheadmesodermis regulatedbyNotchsignalingandthatthecombinationofDaughterlessandTinmanissufficientforectopicCCspecification inmesoderm.Understandingthecellular,genetic,signaling,andtranscriptionalbasisofCCcellspecificationandexpansion shouldacceleratediscoveryofmolecularmechanismsregulatingontogenyoforgansthatcontrolmetabolism. Citation:ParkS,BustamanteEL,AntonovaJ,McLeanGW,KimSK(2011)SpecificationofDrosophilaCorporaCardiacaNeuroendocrineCellsfromMesodermIs RegulatedbyNotchSignaling.PLoSGenet7(8):e1002241.doi:10.1371/journal.pgen.1002241 Editor:NorbertPerrimon,HarvardMedicalSchool,HowardHughesMedicalInstitute,UnitedStatesofAmerica ReceivedApril21,2011;AcceptedJune28,2011;PublishedAugust25,2011 Copyright:?2011Parketal.Thisisa