Time lag between oscillatory pressure and flow affecting accuracy of forced oscillation technique 英文参考文献.docVIP

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Time lag between oscillatory pressure and flow affecting accuracy of forced oscillation technique 英文参考文献.doc

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Time lag between oscillatory pressure and flow affecting accuracy of forced oscillation technique 英文参考文献

OhishiandKurosawaBioMedicalEngineeringOnLine2011,10:65 /content/10/1/65 LETTER TO THE EDITOR OpenAccess Timelagbetweenoscillatorypressureandflow affectingaccuracyofforcedoscillationtechnique JunichiOhishiandHajimeKurosawa* *Correspondence:kurosawa- Abstract thk@m.tohoku.ac.jp DepartmentofOccupational Health,TohokuUniversityGraduate SchoolofMedicine,Sendai,980, Background:Theforcedoscillationtechnique(FOT)isasimplemethodforassessing theoscillatorymechanicsoftherespiratorysystem.Theoscillatoryproperties, Japan respiratorysystemresistance(Rrs)andreactance(Xrs),arecalculatedfromthe oscillatorypressure/flowrelationship.AlthoughtheFOThasbeenawell-established technique,somedetailedexperimentalconditionswouldbedifferentamong institutions. Methods:Weevaluatedwhethertimelagsproducedbytheexperimentalconditions suchasdifferentpositionsofthesensorscanaffecttheaccuracyoftheFOT.Ifthe positionofthepressuresensorisdifferentfromtheflowsensor,atimelagmay occurinthemeasurements.Theeffectofthetimelagwasstudiedbynumerical analysis. Results:RrswasestimatedtobeincreasedandXrsdecreasedwithanincreasein thetimelag,especiallyatahighoscillatoryfrequencyofthemedium-frequency range(5-35Hz).Atthehigh-frequencyrange(10-500Hz),RrsandXrswerestrikingly differentinthevaluesofthetimelag. Conclusion:Atimelagbetweentheoscillatorypressureandflowmaybeinvolved intheaccuracyoftheFOT,suggestingthatitneedstobeminimizedor compensatedforwithsignalprocessing.Researchersshouldpayattentiontosuch detailedexperimentalconditionsoftheFOTapparatus. Theforcedoscillationtechnique(FOT)isasimplemethodforassessingtheoscillatory mechanicsoftherespiratorysystem,whichhasprovidedimportantfindingsinrespira- toryphysiology[1,2].Currently,theFOTusingmulti-frequencysignalssuchaspseudo randomnoiseorimpulsesignalsiswidelyusedinclinicalresearch[3-6].Althoughthe FOT has been a well-established technique, some detailed experimental conditions would be different among institutions. To elucidate the effects of the experimental conditions