Two New Alkaloids from Narcissus serotinus L. 英文参考文献.docVIP

Molecules 2010, 15, 7083-7089; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two New Alkaloids from Narcissus serotinus L. Natalia B. Pigni 1, Strahil Berkov 1, Abdelaziz Elamrani 2, Mohammed Benaissa 2, Francesc Viladomat 1, Carles Codina 1 and Jaume Bastida 1,* 1 Department of Natural Products, Plant Biology and Soil Science, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain 2 Department of Chemistry, Faculty of Sciences Ain Chock, University Hassan II, Casablanca, Morocco * Author to whom correspondence should be addressed; E-Mail: jaumebastida@; Tel.: +34 934020268. Received: 15 September 2010; in revised form: 5 October 2010 / Accepted: 11 October 2010 / Published: 14 October 2010 Abstract: The Amaryllidaceae family is well known for the presence of an exclusive group of alkaloids with a wide range of biological activities. Narcissus serotinus L. is a plant belonging to this family and its geographical distribution is mainly located along the Mediterranean coast. In the present work, specimens collected near Casablanca (Morocco) were used to study the alkaloid content of this species. Starting with 350 g of the whole plant we used standard extraction and purification procedures to obtain fractions and compounds for GC-MS and NMR analysis. As well as five known alkaloids, we isolated two new compounds: 1-O-(3′-acetoxybutanoyl)lycorine and narseronine. The latter has been previously published, but with an erroneous structure. Keywords: Narcissus serotinus; Amaryllidaceae; alkaloids; narseronine; 1-O-(3′-acetoxy- butanoyl)lycorine 1. Introduction Plants belonging to the Amaryllidaceae family are well known for the presence of an exclusive group of alkaloids with a wide range of biological activities [1]. Within this group, the genus Narcissus has been extensively used in traditional medicine to treat a variety of