Two New Acridone Alkaloids from Glycosmis macrantha 英文参考文献.docVIP

Molecules 2011, 16, 4401-4407; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Two New Acridone Alkaloids from Glycosmis macrantha Maizatul Akmal Yahayu 1, Mawardi Rahmani 1,*, Najihah Mohd Hashim 1, Muhammad Aizat Mohd Amin 1, Gwendoline Cheng Lian Ee 1, Mohd Aspollah Sukari 1 and Abdah Md Akim 2 1 Department of Chemistry, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia 2 Department of Biomedical Science, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia * Author to whom correspondence should be addressed; E-Mail: mawardi@.my; Tel.: +60-38-946-6794; Fax: +60-38-943-5380. Received: 24 February 2011; in revised form: 9 May 2011 / Accepted: 16 May 2011 / Published: 27 May 2011 Abstract: Extraction and chromatographic separation of the extracts of dried stem barks of Glycosmis macrantha lead to isolation of two new acridone alkaloids, macranthanine (1) and 7-hydroxynoracronycine (2), and a known acridone, atalaphyllidine (3). The structures of these alkaloids were determined by detailed spectral analysis and also by comparison with reported data. Keywords: Glycosmis macrantha; macranthanine; 7-hydroxynoracronycine; atalaphyllidine 1. Introduction Plant of the genus Glycosmis of the family Rutaceae, are widely distributed throughout the India-Malayan region. They are small trees, commonly found on limestone hills and near coastal areas. Fourteen of the species can be found in Peninsular Malaysia and several members of the genus were traditionally used for the treatment of various diseases such dysentery, fever cough, jaundice, rheumatism, eczema and skin diseases [1,2]. Previous reports indicated that the genus is a rich source of various classes of compounds such as flavonoids, alkaloids and sulphur-containing amides [3-8]. Some of these compounds were reported to exhibit biological activity, particularly the