高致病性猪蓝耳病自然病例与美洲株(VR-2332)人工感染猪的比较病理学.pdfVIP

中国兽医学报 2009 年 4 月第29 卷第4 期 Chin J Vet Sci Apr. 2009 Vo l. 29 No.4 451 高致病性猪蓝耳病自然病例与美洲株(VR-2332) 人工感染猪的比较病理学 高晓磊，刘思当\委忠子，王天户 〈山东农业大学动物科技学院，山东泰安 271018) 摘要z 为了解猪繁殖与呼吸综合征病毒(PRRSV) 美洲株与我国当今流行的高致病性毒株在放病性上的差异，对高 致病性 PRRSV 自然感染病例和美洲株 VR-2332 人工感染猪进行比较病理学研究，探讨 PRRSV 高致病性毒株的 致病特点及发病机制。结果显示，高效病性 PRRSV 会引起发病猪耳和四肢未鹉迅速发纺、皮肤点状出血、急性肺 实变、全身出血性坏死性淋巴结炎、急性炎性脾肿、部分病例脾边缘出血性梗死灶、肾点状出血和胃肠事占膜出血等 膏l 检病变，死亡病猪具有急性出血性败血症的剖检病变特征.全身性淋巴组织急性坏死、重度病毒性脑炎、实质器 官变性坏死及肺继发感染为高致病性 PRRSV 自然感荣病例的组织病变特征，这是导致病猪急性死亡和多继发感 袋的的主要原因。两病毒感染猪的肺和扁桃体免疫纽化染色阳性细胞以及肺和牌电镜下病毒颗粒的分布、形态基 本相同。 关键词:猪蓝耳病;美洲株;高致病性毒株:比较病理学 中圄分类号:5852.65;5852.3 文献标识码:A 文章编号: 1005-4545(2009)04-0451-05 Comparative pathology of piglets natually infected with high-pathogenic PRRSV and artificially infected with American strain PRRSV (VR-2332) GAO Xia o-lei. LIU Si-dang • LOU Zhong-zi. WANG Tian-hu (College of Veterinary Medicine. Shandong Agricultural University. Tai aη .Shandong 271018.China) Abstract: In order to find the different pathogenic traits of high-pathogenic PRRSV prevailing in China and A- merican strain PRRSV (VR-2332) , the pathological characters and pathogenesis of piglets naturally infected with high-pathogenic PRRSV and artjficially intected by American strain (VR-2332) were studied. The results indicated that the typical pathological changes of piglets naturally infected with high-pathogenic PRRSV included quick cyano- sis of tips of feet and ears ,f1ecked bleeding in skin ,acute consolidation of lung ,bleeding necrotic Iymphadenitis.acute splenitis ,hemorrhagic infarct in the border of spleen ,f1 ecked bleeding in kidney as well as gastrointestinal mucous membrane hemorrhage and ulcerations. Dead pigs showed typical changes of acute hemorrhagic sep