转移相关基因-2调控肿瘤侵袭转移的研究.pdfVIP

.744. 临床肿瘤学杂志 2016 年 8 月第 21 卷第 8 期 Chinese Clinical Oncology ,Aul!;. 2016 ,Vo1.21 ,No.8 转移相关基因-2 调控肿瘤侵袭转移的研究* 2∞025 上海上海交通大学医学院附属瑞金医院肿瘤科王起，周尘飞，张俊1 [摘 要] 转移相关基因之(MTA2) 是转移相关基因家族成员之一，其蛋白质序列及功能结构域编码序列与 MTAl 具有 高度同源性。 MTA2 参与构成核小体重构及组蛋白去乙酷化酶(NuRD) 复合物，并可与多种转录因子相互作用，参与基因转录 调控。 MTA2 在多种恶性肿瘤中异常表达，并与肿瘤恶性生物学行为密切相关，提示 MTA2 在肿瘤发生、发展过程中发挥重要 作用。本文将对MTA2 在肿瘤中的表达情况、生物学功能以及在肿瘤侵袭、转移中的相关分子机制等进行综述。 [关键词] 转移相关基因-2(MTA2) ; 肿瘤; 转移; 侵袭 中圄分类号:R730 文献标识码:A 文章编号:1009-0460(2016)08-0744-04 Research on metas幅画 associated gene 2 mediating invasion and metastasis of tumor 阳NG Chω， ZHOU Chenfei , ZHANG Jun. Department 01 Oncology , Ruijin Hospital , School 01 Medicine , Shanghαi Jiω Tong University , Shanghαi 2∞025 ， China Corresponding author: ZHANG Jun , E-mαil: junzhαng10977@ 机 [Abstract] Metastasis associated gene 2 ( MTA2) is a member of metastasis-associated gene family. Protein alignment homology of human MTA proteins and coding se年wnce of functional domain revealed high homology of MTA2 with MTA 1. MTA2 is one of the components of nucleosome remodeling deacetylase (NuRD) complex which have chromatin remodeling and histone deacetylating properties. It can also interact wi出 some transcription factors and involve into gene transcriptional regulation. MTA2 is over-expressed in various kinds of malignancies and closely associated with tumor invasion and metastasis , which indicates that MTA2 may play vital role in tumor metastasis. Herein , we will review the expression , biological function and the molecular mechanism of MTA2 in tumor invasion and metastasis. [Key Words] Metastasis associated gene 2 ( MTA2); Tumor; Me阳tasis; Invasion 转移相关基因-2 (metastasis associated gene 2 , MTA2 )是 的同源性为 680毛。 MTA 家族蛋白质结构在 N 末端高度相 似，含4 个高度保守的结构域:BAH 区域(氨基酸序列 1- 转移相关基因家族成员之一