经直肠超声引导下125碘粒子植入治疗前列腺癌并发症分析.doc

经直肠超声引导下125碘粒子植入治疗前列腺癌并发症分析 　　作者：王启林，李瑞乾，张国颖，赵　斌，雷永虹 作者单位：(云南省肿瘤医院泌尿科，云南 昆明　65000) 　　【摘要】 目的：探讨直肠超声引导125碘粒子植入治疗前列腺癌的临床疗效及并发症分析。方法：回顾性分析我院2009年2月～2011年2月62例患者，随机分为两组，对照组采用全雄激素阻断(双侧睾丸切除+抗雄激素药物)治疗，观察组采用直肠超声引导下125碘粒子植入术治疗，比较两组治疗前后的PSA值变化、并发症发生率及5年生存率。结果：术后2个月，两组患者前列特异性抗原值均有明显下降，但两组相比无统计学意义(P0.05);术后6个月，观察组患者前列特异性抗原明显低于观察组，两组相比有统计学意义(P0.05)。术后对照组患者并发症的发生率为83.3%，观察组患者并发症的发生率为34.4%，两组相比有统计学意义(P0.05)。结论：经直肠超声引导下125碘粒子植入是治疗前列腺癌有效方法，疗效确切，创伤小、定位准确、并发症少，值得临床推广。 　　【关键词】 前列腺癌,全雄激素阻断,125碘粒子 　　[ABSTRACT] Objective： To investigate the clinical efficacy and complication of implanted 125 iodine guided by transrectal ultrasound for prostate cancer. Methods：A total of 62 patients admitted from February 2009 and February 2011 were randomly divided into two groups. Patients in control group were treated by maximal androgen blockade therapy(bilateral testectomy+ antiandrogen drug). While patients in study group were treated with transrectal ultrasound-guided 125 iodine particle implantation treatment. PSA value， complication incidence and 5-year survival rate were observed and compared.Results：After two months， prostate specific antigen value were decreased obviously， but without statistically significant difference between two groups (P0.05); After six months ， prostate specific antigen value was significantly lower in control group than the experimental group (P0.05). Postoperative complications incidence was 83.3% in control group， and 34.4% in experimental group， with significant difference between two groups(P0.05).Conclusion：125 iodine implantation guided by transrectal ultrasound is effective treatment for prostate cancer， with small trauma， accurate positioning and less complications. It is worthy clinical application 　　[KEY WORDS] Prostate cancer; Maximal androgen blockade; 125 iodine particle 　　目前，随着人民生活水平的提高及人口老龄化进程加快，前列腺癌的发病率呈逐年上升趋势[1]。为了寻找更有效的治疗前列腺癌的方法。本院2009年2月～2011年2月共收集前列腺癌患者62例，分别采用全雄激素阻断(双侧睾丸切除+抗雄激素药物)治疗和直肠超声引导下125碘粒子植入术治疗，现报道如下。 　　1　资料与方法 　　1