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ARTICLE
A Systematic Review and Meta-Analysis of the
Pharmacological Treatment of Cancer-Related
Fatigue
Ollie Minton, Alison Richardson, Michael Sharpe, Matthew Hotopf, Patrick Stone
Background Cancer-related fatigue is an important clinical problem. It is common, distressing, and often difficult to
treat. There is a role for drug treatment of cancer-related fatigue, but no consensus has been reached on
which drugs are useful. This systematic review and meta-analysis aims to review the available evidence D
o
and make recommendations for practice and research. w
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o
a
Methods We searched the Cochrane register of controlled trials (through the second quarter 2007), Medline (January d
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