CKD骨矿物质-血管综合征的防治_培训课件.pptVIP

Therapeutic Interventions for Managing Secondary HPT Active vitamin D sterols are widely used for managing secondary HPT in CKD patients. These drugs mimic the effects of endogenous calcitriol, and thereby supplement the low levels found in CKD. Active vitamin D sterols reduce pre-pro-PTH gene transcription and PTH synthesis, resulting in a decrease in serum PTH levels.1 However, active vitamin D sterols also stimulate intestinal calcium and phosphate absorption, which increases serum calcium and phosphate and raises the risk for hypercalcemia and hyperphosphatemia.2 Importantly, hypercalcemi