紫茉莉根水提物对葡萄糖及四氧嘧啶致高血糖小鼠的降血糖作用.pdfVIP

现代食品科技 Modern Food Science and Technology 2011, Vol.27, No.2 紫茉莉根水提物对葡萄糖及四氧嘧啶致高血糖小鼠 的降血糖作用 刘安军，王云霞，李海燕，马天娇，郑国强 （天津科技大学食品工程与生物技术学院，天津 300457） -1 -1 摘要：通过腹腔注射给予葡萄糖、四氧嘧啶建立小鼠高血糖模型，灌胃给予 10 g·kg ·bw 紫茉莉根水提物，连续给药 10 d，葡 萄糖氧化酶法测空腹血糖，研究了紫茉莉根水提物对葡萄糖、四氧嘧啶、葡萄糖+四氧嘧啶致高血糖小鼠空腹血糖的影响。结论表明 -1 -1 按 10 g·kg ·bw 连续 10 d 灌胃给予葡萄糖、四氧嘧啶、葡萄糖+四氧嘧啶诱导的高血糖小鼠，均有极显著的降糖作用，水提物还能提 高模型鼠的胸腺、脾指数，促进其肝、肌糖原的合成,而对各组小鼠的体重没有明显的影响。 关键词：紫茉莉根；降血糖；糖原 文章篇号：1673-9078(2011)2-128-130 Hypoglycemic Effect of Aqueous Extract from Mirabilis jalapa on Diabetic Mice Induced by Administration of Alloxan and Glucose LIU An-jun, WANG Yun-xia, LI Hai-yan, MA Tian-jiao, ZHENG Guo-qiang (College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China) Abstract: To observe hypoglycemic effect of aqueous extract from Mirabilis jalapa on diabetic mice induced by administration of alloxan and glucose, the models of diabetic mellitus were established by ip glouse and alloxan. Aqueous extract was intragastric-administrated to -1 -1 observe the effects in the diabetic mice by 10 g·kg ·bw with ten days standing. Glucose oxidase method was used to measure fasting blood glucose content. Results showed that with 10-day administration by 10 g·kg-1 -1 ·bw in the diabetic mice, the clear hypoglycemic effects were found. And the aqueous extract could significantly increase thymus index, spleen index, hepatic glycogen and muscle glycogen content ，while showed little effects on body-weig