应用在线经颅直流电刺激探查外侧裂后部对失语症恢复的作用.pdfVIP

Chinese Journal of Rehabilitation Medicine, May 2011, Vol. 26, No.5 ·临床研究· 应用在线经颅直流电刺激探查外侧裂后部对 失语症恢复的作用* 1 1,3 1 2 汪 洁 吴东宇 袁 英 陈颂玲 摘要 目的：采用汉语失语症心理语言评价（PACA ）及在线经颅直流电刺激（tDCS ），探查两半球外侧裂后部周围区（PPR ）是 否可以促进失语症语言功能的改善，以及语言功能恢复的可能机制。 方法：利用PACA 对7 例脑卒中后恢复期失语症患者（基底核区损伤4 例，皮质损伤3 例）进行语言评价，同时实施在 线tDCS 。在无刺激、左PPR 区和右PPR 区阳极刺激三种试验条件下进行失语症评价。语言评价任务为听觉词-图匹 配、图命名。 结果：阳极刺激左PPR 区时，图命名成绩显著改善（P0.05 ）；而刺激右PPR 区时，听觉词-图匹配成绩下降（P0.05 ）。 结论：对恢复期失语症患者采用tDCS 阳极刺激左PPR 区，可以提高其图命名成绩，而右PPR 区阳极刺激降低听觉 词-图匹配成绩。其可能机制是阳极刺激左PPR 区，使得该区皮质的兴奋性增高，激活相关语言区，从而提高了患者 的图命名能力；而右PPR 区阳极刺激干扰了左半球的听理解加工，表明脑卒中后失语症的语言恢复以同侧半球代偿 为主。 关键词： 经颅直流电刺激；失语症；心理语言评价; 脑卒中 中图分类号：R743.3 ，R493 文献标识码：A 文章编号：1001-1242（2011 ）-05-0406-05 Effect of on-line transcranial direct current stimulation at posterior perisylvian region on aphasia recovery/ WANG Jie, WU Dongyu, YUAN Ying,et al.//Chinese Journal of Rehabilitation Medicine, 2011, 26(5): 406— 410 Abstract Objective: To investigate whether stimulating bilateral posterior perisylvian regions (PPR) with transcranial direct current stimulation (tDCS) could improve language function of aphasia and its possible mechanism. Method: Seven convalescent aphasic patients after stroke were examined with psycholinguistic assessment in Chi⁃ nese aphasia (PACA). tDCS was applied under three different conditions: tDCS with anodal plate over the left PPR, tDCS with anodal plate over the right PPR, and without stimulation. The language tasks included pic⁃ ture-naming and auditory word-picture matching. Result: The scores of picture naming improved significantly during anodal tDCS over the left PPR(P0.05), while the scores of the auditory word-picture matching decreased during ano